Prediciting Radiation-Induced lung injury through patient-specific lung epithelial ORganoids - PRIOR

eids Universitair Medisch Centrum0 个研究点目标入组 65 人开始时间: 待定最近更新: 2024年4月15日

试验速览

暂无简介。

•* Age * 18-85 years;
•* Clinical suspicion of lung tumor with mediastinal lymph node involvement
•based on enlarged lymph nodes on CT thorax or FDG uptake on PET-CT conform ESMO
•guidelines;
•* Planned bronchoscopy with endobronchial ultrasound (EBUS) with sedation
•(Propofol or benzodiazepine) for standard diagnostic work-up;
•* Clinical performance adequate for undergoing EBUS (according to pulmonary
•physician ordering the diagnostic procedure).

•* Clinical performance too low to undergo EBUS according to pulmonary physician
•ordering the diagnostic procedure;
•* Suspicion of metastasis or stage IV disease on PET-CT or CT-thorax;
•* Inadequate understanding of the Dutch language in speech and writing.
•* Clinical performance too low to receive chemoradiotherapy or proton therapy;
•* Significant co-morbidities such as end stage renal disease, severe
•cardiovascular disease, severe psychiatric disease, end stage COPD, or other
•comorbidity with limited expected survival (<1 year) or WHO performance status
•* Known pre-existent diagnosis of lung fibrosis or newly diagnosed lung
•fibrosis before start of the study;
•* Previous thoracic radiation-treatment.

发起方