Prediciting Radiation-Induced lung injury through patient-specific lung epithelial ORganoids

A0 个研究点目标入组 65 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Age > 18-85 years;
•Clinical suspicion of lung tumor with mediastinal lymph node involvement based on enlarged lymph nodes on CT
•thorax or FDG uptake on PET-CT conform ESMO guidelines;
•Planned bronchoscopy with endobronchial ultrasound (EBUS) with sedation (Propofol or benzodiazepine) for
•standard diagnostic work -up;
•Clinical performance adequate for undergoing EBUS (according to pulmonary physician ordering the diagnostic
•procedure).

•Clinical performance too low to undergo EBUS according to pulmonary physician ordering the diagnostic
•Suspicion of metastasis or stage IV disease on PET-CT or CT-thorax;
•Inadequate understanding of the Dutch language in speech and writing.
•Clinical performance too low to receive chemoradiotherapy or proton therapy;
•Significant co-morbidities such as end stage renal disease, severe cardiovascular disease, severe psychiatric
•disease, end stage COPD, or other comorbidity with limited expected survival (<1 year) or WHO performance
•status >3;
•Known pre-existent diagnosis of lung fibrosis or newly diagnosed lung fibrosis before start of the study;
•Previous thoracic radiation-treatment.

发起方