Excitability Modeling And Correction of Hyperactive Brain Networks in Alzheimer*s disease

Phase 3

Recruiting

• Conditions: neurodegenerative disorders, dementia; memory loss; Alzheimer's dementia

• Registration Number: NL-OMON56020
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 24 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria: fulfilling the diagnostic criteria for probable AD;
between 50-80 years of age; known amyloid status.

Additionally, a signed informed consent for Amsterdam Dementia Cohort (ADC)
(P2016.061) or AHR (P2016.409) is required.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study: cardiac pacemakers, ICD's and other
intracorporeal devices or medication interfering with MEG-signals; severe
claustrophobia.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint consists of MEG-based measures of oscillatory brain<br /><br>activity, functional connectivity and network topology, which indicate the<br /><br>degree of disruption or improvement in brain functioning. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Optimal stimulation parameters as determined by the model, and working memory<br /><br>scores.</p><br>