Translating network hyperexcitability in preclinical familial Alzheimer's disease
Completed
- Conditions
- Alzheimer's DiseaseInheritable Dementia100292991002930510012272
- Registration Number
- NL-OMON49729
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
Potential subjects need to have a dominantly inherited Alzheimer's Disease
(DIAD) mutation and must be at least 18 years of age.
Exclusion Criteria
Participants who show dementia due to (familial) AD will be excluded from the
study. In addition, participants who have for example cardiac pacemakers, ICD's
or other intracorporal devices which excessively interfer with MEG-signals may
be excluded.
Additional contra-indications for MRI scanning (e.g. implanted metals), current
or planned pregnancy and subjects with severe claustrophobia cannot
participate.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Hippocampal and global brain MEG based measures of oscillatory brain activity,<br /><br>represented in total broadband power and E/I balance (from 1/f of the<br /><br>powerspectrum or new method for fE/I, based on DFA and power. </p><br>
- Secondary Outcome Measures
Name Time Method