comparison of intrathecal morphine versus Erector spinae plane block for postoperative pain control in patients with Kidney Disease undergoing kidney Transplantation

Phase 4

Recruiting

Conditions: End stage renal disease,

Registration Number: CTRI/2023/01/049068

Lead Sponsor: Mahatma gandhi hospital

Brief Summary: Post operative pain is a major concern after any surgery.Inadequate control of pain after major surgeries continues to be a cause ofworry since it may be associated with a delay in recovery leading to anincrease in incidence of chronic post surgical pain. At present, there arenumerous methods exist for post operative pain management after major abdominalsurgeries such as intrathecal or intravenous(I.V)opioids, epidural analgesia,and ultrasound guided peripheral nerve blocks,however options for postâ€‘kidneytransplantation analgesia are limited due to associated comorbidities in kidneytransplant recipients.Ultrasound guided regional anaesthesia is an upcoming and rapidly progressivemethod of pain management. The ultrasound guided erector spinae plane block(ESPB) is a newer regional anaesthesia technique currently being explored as a viable optionfor analgesia. ESPB is performed by injecting local anaesthetic in the planebetween the erector spinae muscle and transverse process. Both intrathecalmorphine and ESPB has been investigated for use in post-operative analgesia forvarious surgeries like total abdominal hysterectomy, laparoscopiccholecystectomy, percutaneous nephrolithotomy, open nephrectomy, but there arevery limited studies in regarding there use in kidney transplant recepients. With the hypothesis that both intra-thecal morphine and ultrasoundguided ESPB has effect on post operative pain management So, this study isbeing planned to compare and evaluate both modalities and observe the duration, quality of analgesia and postoperative analgesic consumption in the patients undergoing kidneytransplantation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 60

Inclusion Criteria

1American Society of Anaesthesiologists (ASA) III patients 2Age group of 20-60 years 3Patient with written valid consent 4Patient undergoing renal transplant surgery.

Exclusion Criteria

1Patient refusal 2History of allergy to study drug 3Contraindication to spinal puncture/regional block (e.g. bleeding diathesis, neurologic dysfunction, and recent systemic or local infection); 4Insufficient comprehension to use the PCA device, 5History of drug abuse, 6Severe cardiovascular disease 7Patient with neurological disorder 8Recent use of psychoactive or analgesic medication.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate and compare the effect of intrathecal morphine versus ESPB in terms of duration and quality of analgesia and post operative analgesic consumption	postoperative hours

Secondary Outcome Measures

Name	Time	Method
Effect on catheter related bladder discomfort	To observe any procedure and drug related complications

Trial Locations

Locations (1): Mahatma gandhi hospital
🇮🇳
Jaipur, RAJASTHAN, India
Mahatma gandhi hospital
🇮🇳Jaipur, RAJASTHAN, India
saurabh mittal
Principal investigator
8087439644
saurabh.mittal013@gmail.com