Effects of a Whole Body Vibration Training in Patients After Lung Transplantation

Not Applicable

Completed

• Conditions: Patients Following Lung Transplantation (Single and Double)
• Interventions: Other: Pulmonary rehabilitation + whole body vibration training

• Registration Number: NCT01480960
• Lead Sponsor: Schön Klinik Berchtesgadener Land

Brief Summary

Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients following lung transplantation. Exercise training has been shown to be a cornerstone of an inpatient rehabilitation program to reduce muscle dysfunction and improve exercise performance. In our study we will investigate the benefit of a whole body vibration training in addition to a standard pulmonary rehabilitation program that includes endurance and strength training. We will include a total of 140 patients (70 patients \< 1 year after lung Transplantation and 70 patients \> 1 year after lung Transplantation). Our hypothesis is that an addtitional whole body vibration training produces a greater benefit to exercise capacity in lung transplantat patients (LTx).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-11-24
• Study First Submitted QC: 2011-11-24
• Study First Posted: 2011-11-29
• Study Start: 2012-01
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-23
• Last Update Posted: 2016-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• participation in an inpatient rehabilitation program
• double or single lung transplantation due to chronic obstructive pulmonary disease, Alpha-1-antitrypsine deficiency, interstitial lung disease

Exclusion Criteria

• severe exacerbation in the last 4 weeks with the necessity of delivering antibiotics/ corticosteroids
• non-compliance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Whole body vibration training	Pulmonary rehabilitation + whole body vibration training	Whole body vibration training in addition to pulmonary rehabilitation

Primary Outcome Measures

Name	Time	Method
change in 6-minute walking distance	change from baseline to day 21

Secondary Outcome Measures

Name	Time	Method
change in Fmax	change from baseline to day 21	maximum isometric quadriceps force
change in fibre cross sectional area	change from baseline to day 21	cross sectional area of the M.rectus femoris, measured by ultrasound
change in body cell mass	change from baseline to day 21	measured by bio-impedance analysis
change in Wmax	change from baseline to day 21	maximum workload in incremental cycling test
change in quality of life	change from baseline to day 21	SF-36 questionnaire and CRQ questionnaire
change in IGF-1	change from baseline to day 21	IGF-1, measured in a blood sample
change in chair rise time	change from baseline to day 21	chair rise test: to get from a sitting position to a standing, measuring the time for 5 repetitions

Trial Locations

Locations (1)

Schön Klinik Berchtesgadener Land; 🇩🇪 Schönau am Königssee, Germany