utrition supplementation and immunity in athletes

Phase 1

Completed

• Conditions: Gastrointestinal illness; Upper respiratory tract illness; Alternative and Complementary Medicine - Other alternative and complementary medicine; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12611000771954
• Lead Sponsor: Australian Institute of Sport

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Normal biochemistry and haematology, athletic training background of 3 years, a minimal maximal oxygen uptake (VO2max) of 45 ml/kg/min for women and 50 ml/kg/min for men, no use of immunomodulatory medicines.

Exclusion Criteria

No history of irritable bowel syndrome/disease, crohn's disease, autoimmune conditions.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Faecal short chain fatty acids (butyrate, acetate and propionate) were determined by gas liquid chromatography[Day 0, day 12 (mid-study) and day 28];Serum cytokines including interleukin (IL) 1RA, 6, 8, 10, granulocyte colony stimulating factor, interferon gamma, tumor necrosis factor alpha. All cytokines are measured by microarray[Day 0 (baseline), day 12 (mid-study) and day 28.];Quantitation of total faecal bacteria by microarray and quantitative polymerase chain reaction.[Day 0 (baseline), day 12 (mid-study) and day 28.]

Secondary Outcome Measures

Name	Time	Method
Gastrointestinal and upper respiratory symptoms will be determined by the self reported questionnaire. Symptoms of gastrointestinal illness include flatulance, stomach rumbles, diarrhoea, bloating. Symptoms of respiratory illness include scratchy throat, sore throat, coughing, sneezing, runny nose, blocked nose and headache. An episode will include two or more symptoms for 3 or more days.[Daily throughout the course of supplementation];Salivary antimicrobial proteins and antibodies including immunoglobulin A (SIgA), lactoferrin (Lf) and lysozyme (Ly). All salivary measures will be analysed by commercial enzyme linked immunoassay (SIgA - Stratech Scientific, Lf- Calbiochem and Ly - Saphhire Bioscience)[Day 0, day 12 (mid-study) and day 28]