Acquired Von Willebrand Syndrome in Severe Aortic Stenosis
- Conditions
- BleedingVon Willebrand DiseaseAortic Stenosis
- Registration Number
- NCT00805051
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. We hypothesized that the diagnosis of acquired von Willebrand syndrome influence perioperative blood loss in patients undergoing open cardiac valve replacement.
- Detailed Description
Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. After written consent and an extended anamnesis of existing coagulopathy, we take three blood samples in these patients: before surgery, on the day after surgery and 4 weeks after surgery. We determine von Willebrand factor in lab and by a point-of-care platelet function analyzer (Multiplate TM). We measure amount of mediastinal drainage after 24 hours and blood product consumption in these patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Severe aortic stenosis (Orifice area < 1 cm2)
- missing consent
- severe hepatic or renal disfunction
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount of mediastinal drainage in the first 24 hours 24 hours
- Secondary Outcome Measures
Name Time Method Amount of given blood products in the first 24 hours 24 hours
Trial Locations
- Locations (1)
Department of Anaesthesia, University of Basel Hospital
🇨🇭Basel, Switzerland