The acquired von Willebrand syndrome coexisting with cardiovascular diseases Study
Not Applicable
Recruiting
- Conditions
- Various circulatory diseases including aortic stenosis, mitral regurgitation, hypertrophic cardiomyopathy, pulmonary hypertension, acute pulmonary embolism, mechanical circulatory support, congenital heart diseases, and small-intestinal bleeding
- Registration Number
- JPRN-UMIN000018135
- Lead Sponsor
- The Research Group for the AVec Study (Main Offiece at IDAC,Tohoku University)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 2300
Inclusion Criteria
Not provided
Exclusion Criteria
none
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This study is a prospective observational study to evaluate and elucidate incidence and clinical condition such as values obtained by laboratory examinations of aVWS and related bleeding events in each target circulatory disease by transverse and longitudinal analyses. Further, patients with small intestinal bleeding will be also enrolled and the contribution of cardiovascular disease-related aVWS would be also evaluated in the same way.
- Secondary Outcome Measures
Name Time Method Elucidation of relationship between aVWS or bleeding events and values of blood examination such as ADAMTS13 activity and multiuser analysis of VWF, in each circulatory disease. aVWS-related bleeding sites such as gastrointestinal tract in each circulatory disease. Elucidation of set-up that possibly inducing aVWS under treatment of mechanical circulatory support device