Cardiovascular Riskprofile in Women: Microvascular Status
Recruiting
- Conditions
- Migraine100192311003861210047066
- Registration Number
- NL-OMON44797
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Age between 40 and 60 years
Female
Capable and willing to provide informed consent
Stroke cohorts: stroke diagnosed by cerebral imaging and verified in clinical
records
Preeclampsia cohorts: fulfil criteria for diagnosis PE, verified in clinical
records
PCOS cohorts: fulfil Rotterdam criteria for diagnosis PCOS
Exclusion Criteria
Insufficient mastery of Dutch
Any serious illness that can compromise study participation
Current pregnancy
Stroke cohorts: TIA, retinal infarction or venous infarction
Contra-indications for MRI
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* White matter hyperintensities (WMH) load on brain Magnetic Resonance Imaging<br /><br>(MRI) graded in volume.<br /><br>* Endothelial function measured as dermal blood flow changes (DBF) after Local<br /><br>Thermal Hyperaemia (LTH) using Laser Doppler Perfusion imaging (LDPI) expressed<br /><br>in arbitrary units.<br /><br>* Endothelial function measured as Reactive Hyperaemia Index (RHI) using<br /><br>Peripheral Arterial Tonometry (EndoPAT) expressed in arbitrary units.</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Location of white matter hyperintensities<br /><br>* Location of stroke<br /><br>* Stroke subtype (large artery, cardioembolism, small vessel occlusion, other<br /><br>determined, undetermined)<br /><br>* Comparison of LTH measurements after pre-treatment with EMLA or LNMMA<br /><br>* Serum markers for endothelial dysfunction and gonadal hormone levels</p><br>