Microvascular and Cardiovascular Status of Females with and without Migraine - VASCULAR

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月9日

适应症

试验速览

暂无简介。

•In order to be eligible to participate in this study, a subject must meet all
•of the following criteria:
•- Women aged 40-60 years without a history of ischemic stroke, preeclampsia and
•PCOS (i.e. control group, free of comorbidities which have been investigated in
•our previous multicenter CREW-MIST consortium);
•- If the participants are still fertile, they should fulfill at least one of
•the following criteria:
•o a regular menstrual cycle of 25-30 days as measurements will be performed in
•the middle of their cycle;
•o use of oral combination pill and inclusion should not take place in the
•withdrawal week;
•o use of Mirena, Kyleena, Liletta, and Skyla (hormonal intrauterine devices)
•or Nexplanon/Implanon (etonogestrel birth control implant).
•- Capable and willing to provide informed consent.

•A potential subject who meets any of the following criteria will be excluded
•from participation in this study:
•- A medical history or self-reported symptoms of conditions related to
•(peripheral) vascular disease, e.g. cardio- or cerebrovascular events,
•peripheral arterial disease, chronic kidney disease, (pre)diabetes mellitus,
•uncontrolled chronic hypertension, congestive heart failure, hyperlipidemia,
•hypercholesterolemia, et cetera;
•- Current use of any drugs as primary or secondary prevention of cardiovascular
•- Current or former non-incidental smoking (all substances);
•- Alcohol consumption of more than seven alcohol units per week;
•- Current or prior substance dependence/addiction (alcohol, illicit drugs,
•tranquillizers, narcotics, analgesics);
•- Current pregnancy;
•- Insufficient mastery of Dutch or English;
•- Any other (serious) illnesses that can compromise study participation;
•- Skin conditions (e.g. psoriasis, eczema, rosacea), scars or tattoos on
•ventral side of lower arm or digits;
•- (Any known) allergy for EMLA or L-NMMA;
•- Any COVID-19 related symptoms (we will perform a screening by phone) on the
•day of the measurements.

发起方