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Clinical Trials/NCT01583803
NCT01583803
Unknown
Not Applicable

Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels

Queen Mary University of London1 site in 1 country24 target enrollmentJune 2012
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ConditionsCardiovascular Disease

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiovascular Disease
Sponsor
Queen Mary University of London
Enrollment
24
Locations
1
Primary Endpoint
Bacterial species identification
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Females have a lower incidence of hypertensive and cardiovascular disorders that may relate to differences in nitrogen oxides in the blood and saliva. Some nitrogen oxides are recycled with the help of oral bacteria to nitric oxide which is protective against vascular disorders. This study will test the hypothesis that females have different numbers and species of these nitrogen-oxide reducing bacteria.

Registry
clinicaltrials.gov
Start Date
June 2012
End Date
June 2017
Last Updated
9 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Amrita Ahluwalia

Professor of Vascular Pharmacology

Queen Mary University of London

Eligibility Criteria

Inclusion Criteria

  • •Healthy subjects aged 18-45 who have volunteered themselves and are willing to sign the consent form

Exclusion Criteria

  • •Healthy subjects unwilling to consent
  • •History of hypertension, diabetes or hypertensive on BP measurement
  • •Pregnant, or any possibility that a subject may be pregnant unless in the latter case a pregnancy test is performed with a negative result
  • •History of any serious illnesses, including recent infections or trauma
  • •Subjects taking systemic medication (other than the oral contraceptive pill)
  • •Subjects with self-reported use of mouthwash or tongue scrapes
  • •Subjects with recent or current antibiotic use (within 3 months)
  • •Subjects with a history, or recent treatment of (within last 3 months) of any oral condition (excluding caries), including gingivitis, periodontitis and halitosis

Outcomes

Primary Outcomes

Bacterial species identification

Time Frame: At baseline

Secondary Outcomes

  • Bacterial count(At baseline)
  • Blood pressure(At baseline)
  • Nitrogen oxide levels in biological fluids(At baseline)
  • Oral nitrate reduction(At baseline)

Study Sites (1)

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