High-flow Nasal Cannula Oxygen Therapy for Ischemic Stroke Patients With Dysphagia and Obstructive Sleep Apnea
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebral Infarction
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- apnea-hypopnea index
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
High flow nasal cannula (HFNC) ventilation therapy was found to improve the severity of obstructive sleep apnea in non-stroke subjects. The investigators hypothesized that HFNC might be effective in stroke patients with dysphagia who needed nasogastric tube feeding and can not receive continuous positive airway pressure ventilation for obstructive sleep apnea.
Investigators
CHEN,CHUNG YAO
Physician, associate professor, department of physical medicine and rehabilitation
Chang Gung Memorial Hospital
Eligibility Criteria
Inclusion Criteria
- •ischemic stroke patients with dysphagia and obstructive sleep apnea who need nasogastric tube feedings
Exclusion Criteria
- •congestive heart failure, unconsciousness, chronic obstructive pulmonary disease, intracranial hemorrhage or malignancy, and unstable medical and neurological conditions
- •central sleep apnea
Outcomes
Primary Outcomes
apnea-hypopnea index
Time Frame: once at polysomnography study night when receive high flow nasal cannula titration study
respiratory inductance plethysmography sum (RIPsum) without calibration to score apnea and hypopnea events (American Academy of Sleep Medicine alternative criteria)
oxyhemoglobin desaturation index
Time Frame: once at polysomnography study night when receive high flow nasal cannula titration study
number of times per hour of sleep that the blood's oxygen saturation level drops by ≥ 3% from baseline
Secondary Outcomes
- heart rate variability(baseline and 1 week after high flow nasal cannula therapy)
- pulse wave velocity(baseline and 1 week after high flow nasal cannula therapy)