High-flow Nasal Cannula Therapy in the Treatment of Acute Carbon Monoxide Poisoning
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Carbon Monoxide Poisoning
- Sponsor
- Università degli Studi del Piemonte Orientale "Amedeo Avogadro"
- Enrollment
- 96
- Locations
- 1
- Primary Endpoint
- COHb reduction at 90 minutes
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of the study is to test whether oxygen therapy delivered through high-flow nasal cannula devices in patients admitted to the emergency department for acute carbon monoxide poisoning is superior to the non-rebreathing oxygen face mask therapy with a 15 L/minute oxygen flow (currently the first-line therapy), in terms of reduction of carboxyhemoglobin (COHb) concentration and delayed neurological sequelae incidence.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age v 18 years
- •Carbon monoxide intoxication as major problem leading to emergency department admission
- •Carboxyhemoglobin (COHb) concentration 10% at the time of enrolment
Exclusion Criteria
- •Age \< 18 years
- •Glasgow coma scale ≤ 13
- •Refusal to give consent
Outcomes
Primary Outcomes
COHb reduction at 90 minutes
Time Frame: 90 minutes
Patients in the High-flow nasal cannula group and patients in the non-rebreathing oxygen mask group will be compared in terms of COHb reduction at 90 minutes. The hypothesis is that in patients treated with high flow nasal cannula the reduction in COHb at 90 minutes will be significantly different compared to patients treated with non-rebreathing oxygen mask.
Secondary Outcomes
- Variation in the incidence of delayed neurologic sequelae(6 weeks)
- Variation in serum lactate concentration(6 weeks)
- Variation in serum troponin concentration(6 weeks)
- Variation in S100B levels concentration(6 weeks)