Effectiveness of High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia: A Randomised Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Preoxygenation
- Sponsor
- Erasme University Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Functional Residual Capacity (FRC) variation
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia. The HFNC interface is compared to a standard anesthesia FaceMask (FM) preoxygenation with Continuous Positive Airway Pressure (CPAP), the current gold standard procedure for obese induction.
The interest of HFNC preoxygenation is to increase the "safe apnea time" before critical arterial desaturation, useful in the management of difficult airways, especially in subjects with reduced respiratory reserves such as the obese.
Investigators
Francesco Ricottilli, MD
Resident, Department of Anesthesiology
Erasme University Hospital
Eligibility Criteria
Inclusion Criteria
- •Surgery with the need for general anesthesia with muscle relaxation
- •ASA (American Society of Anesthesiologists) physical status score II-III
- •BMI \> 35
Exclusion Criteria
- •Severe respiratory disease (acute respiratory failure, Chronic obstructive pulmonary disease COPD, parenchymal pneumopathies,...)
- •Severe nasal pathology (malformation, stenosis)
- •Criteria or previous difficult intubation
- •BMI \> 50
- •Chest circumference \> 150cm
- •Implanted electronic device (pacemaker, neurostimulator, ...)
- •Pregnancy
Outcomes
Primary Outcomes
Functional Residual Capacity (FRC) variation
Time Frame: 20 minutes
The difference of FRC, estimated by lung Electrical Impedance Tomography (EIT), during general anesthesia induction (from a base period to the mechanical ventilation).
Secondary Outcomes
- Time of safe apnea(20 minutes)
- Lowest SpO2(20 minutes)
- Preoxygenation Comfort(6 hours)