Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
- Conditions
- Post-operative Pulmonary Complications
- Registration Number
- NCT03024112
- Lead Sponsor
- University of Colorado, Denver
- Brief Summary
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients. The Investigators hypothesis is that prophylactic HFNC oxygen, as compared to standard oxygen treatment, will reduce the incidence of postoperative pulmonary complications, improve post-operative pulmonary function, and reduce Intensive Care Unit (ICU) and hospital length of stay.
- Detailed Description
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients. The Investigators hypothesis is that prophylactic HFNC oxygen, as compared to standard oxygen treatment, will reduce the incidence of postoperative pulmonary complications, improve post-operative pulmonary function, and reduce ICU and hospital length of stay.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 51
- Undergoing Thoracic surgery
- Planned admission to ICU after surgery
- Younger than 18
- Pregnant
- Breast feeding
- Known diagnosis of obstructive sleep apnea
- Current or previous lung transplant
- Pneumonectomy
- Home oxygen greater than 4L/minute
- Inability to adhere to assigned treatment prior to 48 hours of surgery or until transferred to a floor
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Number of Participants With Post-operative Pulmonary Complications 30 days The primary outcome "post-operative pulmonary complication" is defined as present if any one of the following criteria are met:
* SpO2 \< 90% with FiO2 ≥ 50%
* Dyspnea at rest
* Respiratory rate \> 25 breaths/min
* Active use of accessory respiratory muscles
* PaO2/FiO2 ratio \< 200
* Escalation of therapy to non-invasive ventilation
* Re-intubation
* Occurrence of hospital-acquired pneumonia
* Re-admission to the ICU
- Secondary Outcome Measures
Name Time Method Hospital Length of Stay 30 days length of stay from hospital admission to hospital discharge
Lowest Oxygen Saturation Level Measured 30 days Lowest oxygen saturation level measured during hospitalization from admission to discharge
ICU Length of Stay 30 days
Trial Locations
- Locations (1)
Unversity of Colorado Hospital
🇺🇸Aurora, Colorado, United States
Unversity of Colorado Hospital🇺🇸Aurora, Colorado, United States