Effects of High Flow Nasal Cannula on Breathing and the Respiratory System Parameters
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Czech Technical University in Prague
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this study is a detailed investigation of the effect of High Flow Nasal Oxygenation (HFNO) on respiratory system characteristics and ventilation parameters in healthy adult subjects and the subsequent use of measured data to answer the following questions:
What level of positive end expiratory pressure (PEEP) causes a HFNO with different flow rates? Does HFNO work as pressure support or does it act more like a Continuous Positive Airway Pressure (CPAP) ventilation?
Detailed Description
High Flow Oxygen through nasal cannula is widely used in the setting of hypoxemic respiratory failure of heterogenous etiology with very good patients compliance. However, the evidence of what level of PEEP or pressure support (if any) with different flow rates is weak. Our goal is to determine these effects and compare them with standard approach with non-invasive ventilation via full face mask.
Investigators
Eligibility Criteria
Inclusion Criteria
- •healthy volunteers willing to participate
Exclusion Criteria
- •general contraindications for oesophageal catheter insertion: oesophageal varices, bleeding disorders (including anticoagulant medication), diverticulitis, oesophageal tumors, history of recent oesophageal/gastric surgery, recent epistaxis,
- •sinusitis
- •allergy to local anesthetics
- •subject refusal
Outcomes
Primary Outcomes
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on conventional non-invasive ventilation (NIV).
Time Frame: 1 hour
Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20 on conventional NIV.
Measurement of inspiratory pressure, pressure in a hypopharynx and pleural pressure estimation using oesophageal catheter on High flow nasal oxygenation (HFNO).
Time Frame: 1 hour
Using measurement of several pressures - inspiratory, oesophageal, nasopharyngeal (cm of H20) on High flow nasal oxygenation (HFNO).
Monitoring of EIT during spontaneous ventilation with High flow nasal oxygenation (HFNO).
Time Frame: 1 hour
EIT for description of distribution of ventilation with HFNO with different flow rate levels (litres per minute).
Monitoring of EIT during spontaneous ventilation on conventional non-invasive ventilation (NIV).
Time Frame: 1 hour
EIT for description of distribution of ventilation on conventional NIV at different levels of PEEP (cm H20).
Calculation of Pressure Time Product (PTP) for estimation of Work of Breathing (WOB).
Time Frame: up to 8 weeks
Compare PTP between conventional NIV and HFNO.