NCT02648958已完成不适用
Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Unilateral Total Knee Replacement - a Randomized, Controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- changes of malondialdehyde (μmol/L)
研究概览
简要总结
Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society Anesthesiologists classification I-III
排除标准
- •use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree
研究组 & 干预措施
Control group
Placebo Comparator
The control group received saline instead of dexmedetomidine.
干预措施: normal saline (Drug)
Dexmedetomidine group
Experimental
The dexmedetomidine group received the dexmedetomidine.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
changes of malondialdehyde (μmol/L)
时间窗: up to 1 day
次要结局
- changes of interleukin-6 (pg/ml)(up to 1 day)
研究者
研究点 (1)
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