Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Not Applicable

Completed

• Conditions: Arthroplasty, Replacement
• Interventions: Drug: normal saline; Drug: Dexmedetomidine

• Registration Number: NCT02648958
• Lead Sponsor: Yonsei University

Brief Summary

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2015-12-06
• Status Verified: 2016-01
• Study Start: 2016-01
• Study First Submitted QC: 2016-01-05
• Study First Posted: 2016-01-07
• Primary Completion: 2017-07-31
• Study Completion: 2017-07-31
• Last Update Submitted: 2018-06-12
• Last Update Posted: 2018-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• American Society Anesthesiologists classification I-III

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Exclusion Criteria

• use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	normal saline	The control group received saline instead of dexmedetomidine.
Dexmedetomidine group	Dexmedetomidine	The dexmedetomidine group received the dexmedetomidine.

Primary Outcome Measures

Name	Time	Method
changes of malondialdehyde (μmol/L)	up to 1 day

Secondary Outcome Measures

Name	Time	Method
changes of interleukin-6 (pg/ml)	up to 1 day

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of