The Neuroprotection Effect of Dexmedetomidine
- Registration Number
- NCT03927963
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
The brain protection effect of dexmedetomidine has been approved in several studies.
Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia.
The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used.
The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 70
- ASA class I,II patient needs operation of intracranial aneurysmal clipping without SAH
- Any history of neurologic disease, dementia
- Allergic history of propofol or dexmedetomidine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description propofol Propofol - dexmedetomidine Dexmedetomidine -
- Primary Outcome Measures
Name Time Method The concentration of inflammatory markers Day 2 after operation IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
The concentration of norepinephrine Day 2 after operation NE (nmol/l)
- Secondary Outcome Measures
Name Time Method The frequency of hypotension or hypertension during operation