The Anti-inflammatory Effect and Hemodynamic Stability of Dexmedetomidine in Aneurysmal Clipping Operation; Compare With Propofol
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 主要终点
- The concentration of inflammatory markers
研究概览
简要总结
The brain protection effect of dexmedetomidine has been approved in several studies.
Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main role of the protection effect. In many studies reported the advantage of dexmedetomidine as a substitution of other sedative drugs for anesthesia.
The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly propofol is used.
The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory markers and research the hemodynamic stability of dexmedetomidine compared to propofol in aneurysmal clipping operation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA class I,II patient needs operation of intracranial aneurysmal clipping without SAH
排除标准
- •Any history of neurologic disease, dementia
- •Allergic history of propofol or dexmedetomidine
研究组 & 干预措施
propofol
干预措施: Propofol (Drug)
dexmedetomidine
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
The concentration of inflammatory markers
时间窗: Day 2 after operation
IL-6, IL-8, IL-10 ,TNF-a (pg/ml)
The concentration of norepinephrine
时间窗: Day 2 after operation
NE (nmol/l)
次要结局
- The frequency of hypotension or hypertension(during operation)
研究者
Jiyoung Yoo
Assistant professor
Ajou University School of Medicine