Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Myocardial innervation pattern on 123I-mlBG SPECT.
研究概览
简要总结
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied. We sought to describe the reinnervation status of adult patients long after the ASO, to identify areas of myocardial perfusion/innervation mismatch and to assess the relation of innervation status and exercise capacity.
详细描述
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied. We sought to describe the reinnervation status of adult patients long after the ASO, to identify areas of myocardial perfusion/innervation mismatch and to assess the relation of innervation status and exercise capacity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with transposition of the great arteries repaired with the arterial switch.
- •Patients aged of more than 18 years-old.
排除标准
- •Pregnancy or breast-feeding.
- •Denial of informed consent.
结局指标
主要结局
Myocardial innervation pattern on 123I-mlBG SPECT.
时间窗: 1 day
To describe the myocardial reinnervation pattern of a cohort of patients with TGA long after ASO using cardiac nuclear imaging.
次要结局
- Myocardial innervation perfusion mismatch defects on cardiac nuclear imaging.(1 day)
- Myocardial perfusion defects on cardiac nuclear imaging.(1 day)
- Treadmill exercise test.(1 day)
- 24 hours ECG Holter monitoring .(1 day)