Healthspan Connect Programme of Research
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100,000
- 主要终点
- Incidence of early-onset colorectal cancer (EOCRC)
研究概览
简要总结
Healthspan Connect is a new research programme designed to understand what helps people stay healthy as they age. The programme will explore how lifestyle, environment, genetics, and social factors influence healthy ageing and overall wellbeing.
The programme will recruit participants aged 12 years and older across the UK. By including adolescents, the programme aims to understand how early life behaviours and experiences shape long-term health. There is no upper age limit, and people from all backgrounds are encouraged to participate. Special pathways ensure that young participants provide consent in an age-appropriate way.
Healthspan Connect is a digital and home-based study, meaning participants can take part from home using smartphones, computers, and online surveys. Participants may also be asked to collect samples such as blood, saliva, stool, urine, or other biological specimens at home using easy-to-use kits. In some sub-studies, participants may be invited to attend research visits for additional tests, scans, or clinical assessments. Family members and close contacts may also be invited to participate in some studies.
Through Healthspan Connect, researchers aim to:
- Identify the biological, environmental, and social factors that help people live longer, healthier lives.
- Understand how different groups, including those historically underrepresented in research, experience ageing.
- Explore ways to support behaviour changes that improve health over the lifespan.
- Provide near real-time information to inform health policies and interventions.
Participants may also be asked for permission to link their information with health records, education records, and environmental data to better understand health outcomes over time.
This programme will serve as a flexible platform for multiple sub-studies, allowing participants to contribute to a wide range of research questions related to healthy ageing, resilience, and long-term health. All data and biological samples will be stored securely and used to advance scientific knowledge, with participant privacy carefully protected.
详细描述
1. **SUMMARY**
**a) Rationale**
Healthspan Connect is a new Programme of Research aimed at understanding the life course determinants of healthy lifespan and gain real--time epidemiological insights into health--policy relevant questions.
Healthspan Connect will study healthy volunteers and use digital and remote methods to support healthspan and ageing research, as well as study multiple long-term conditions. The study builds from the ZOE Health study, which Steves designed, with a view to creating capability for rapid scientific answers to policy driven research questions and will also be guided in part by CARICE (Centre for Ageing Resilience in a Changing Environment), a KCL-led research and policy centre on ageing resilience directed by Steves. Healthspan Connect, which will be a vehicle for agile research and the programme sub-studies preferentially focussed on answering clinically and policy relevant research questions.
Healthy ageing and an extended health span are essential as they directly impact quality of life, individual well-being, and societal sustainability. With populations ageing globally, the objective is not only to increase life expectancy but to ensure that these additional years are lived in good health, free from chronic diseases and disabilities. A longer health span enables individuals to maintain their independence, continue contributing to their communities, and enjoy a better quality of life in their later years. Moreover, promoting healthy ageing alleviates the strain on healthcare systems and social care, which can become overburdened by the rising incidence of age-related diseases. By prioritising healthy ageing, this research aims to enhance overall life satisfaction, reduce healthcare costs, and foster more resilient societies where older adults remain active, engaged, and healthy for as long as possible. Additionally, it is crucial to involve underrepresented populations in ageing research to ensure that the benefits of health span extension are equitably distributed. Understanding how ageing and health resilience manifest in diverse groups, including those historically under-represented in research, will enable the development of more inclusive public health strategies and interventions that address the needs of all individuals as they age.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 12 years or older at time of enrollment.
- •Resident in the United Kingdom.
- •Able to participate in the study using digital tools (smartphone, tablet, or computer).
- •Able to provide informed consent (digital consent accepted).
- •For participants aged 12-15 years: must have parent/guardian consent in addition to their own assent.
排除标准
- •Individuals unable to provide informed consent (or parental consent where applicable).
- •Individuals not resident in the UK.
- •Individuals unable to complete study requirements due to lack of internet access, inability to use digital devices, or severe digital literacy barriers.
结局指标
主要结局
Incidence of early-onset colorectal cancer (EOCRC)
时间窗: Through study completion, anticipated ≥10 years
Primary outcome for the first sub-study under the Healthspan Connect programme of research (PROSPECT UK). Defined as a new diagnosis of colorectal cancer before age 50. Confirmed via data from Electronic Health Record Linkage.
Incidence of early-onset colorectal adenoma (EOCA)
时间窗: Through study completion, anticipated ≥10 years
Primary outcome for the first sub-study under the Healthspan Connect programme of research (PROSPECT UK). Defined as a new diagnosis of colorectal adenoma before age 50. Confirmed via data from Electronic Health Record Linkage.
次要结局
未报告次要终点