Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy

Completed

Conditions: Acute Myeloid Leukemia
Acute Undifferentiated Leukemia
Biphenotypic Leukemia
Myelodysplastic Syndrome
Acute Lymphoblastic Leukemia
Non-Hodgkin's Lymphoma

Interventions: Procedure: MRI and cognitive evaluation
Procedure: brain MRI study and a brief neuropsychological evaluation

Brief Summary: The purpose of this study is to learn about possible changes in brain anatomy and in thinking abilities, such as memory skills, in patients with cancer who receive treatment with chemotherapy alone or in combination with total body radiation before undergoing stem cell transplantation.

Recruitment & Eligibility

Inclusion Criteria

Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS), Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission at the time of enrollment
Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI) and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative allogeneic HSCT
Between 18 and 70 years of age.
Are English speaking.
Have capacity to give consent.

Healthy Control Inclusion Criteria:

Exclusion Criteria

Patients with signs and/or symptoms of central nervous system disease as determined by their physician or by a brain MRI, either at the time of enrollment or during the study period.
With disease progression at the time of enrollment or during the study period
With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
With a history of a neurological disorder, neurodegenerative disease, or traumatic brain injury with loss of consciousness
With standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

Exposure to chemotherapy or radiation therapy for any medical condition
With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia
With a history of neurological disorders, neurodegenerative disease, or traumatic brain injury with loss of consciousness
With standard contraindications to MRI examinations

Arm && Interventions

Group	Intervention	Description
B	MRI and cognitive evaluation	Chemotherapy Alone Conditioning Regimen Twenty (20) patients will undergo conditioning treatment with an all chemotherapy regimen prior to receiving an allogeneic or an autologous HSCT.
A	MRI and cognitive evaluation	TBI and Chemotherapy Conditioning Regimen. Twenty (20) patients will undergo conditioning treatment with TBI and chemotherapy prior to receiving a myeloablative allogeneic or an autologous HSCT.
C	brain MRI study and a brief neuropsychological evaluation	A cohort of twenty (20) healthy controls, frequency matched on age, gender, and education, will be recruited at WCMC to participate in the study.

Primary Outcome Measures

Name	Time	Method
assess changes in hippocampal volume & white matter integrity prospectively in adult ca pts who get treatment w/i chemotherapy alone or in combination with total body irradiation (TBI) before undergoing hematopoietic stem cell transplantation.	conclusion of the study

Secondary Outcome Measures

Name	Time	Method
assess memory and executive functions prospectively in these patients. We will investigate whether there is an association between structural brain changes and cognitive performance.	conclusion of the study

Locations (2): Memorial Sloan Kettering Cancer Center
🇺🇸
New York, New York, United States
Weill Cornell Medical Center
🇺🇸
New York, New York, United States

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