Serum Amyloid A in Women With Unexplained Infertility

Completed

• Conditions: Infertility

• Registration Number: NCT03918200
• Lead Sponsor: Ain Shams Maternity Hospital

Brief Summary

High follicular fluid amyloid A level is associated with reduced pregnancy rate.

The aim of this study was to find an association between serum level of amyloid A and unexplained infertility.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-01
• Primary Completion: 2019-03-10
• Study Completion: 2019-03-10
• Status Verified: 2019-04
• Study First Submitted: 2019-04-15
• Study First Submitted QC: 2019-04-16
• Last Update Submitted: 2019-04-16
• Study First Posted: 2019-04-17
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

1. women with unexplained infertility (unprotected, regular intercourse for at least 2 years).

2. Nulligravida ,Regular mensturation.

3. Age less than 40 years .

4. Normal parameters (in the study group):

   • hormonal profile (day 2 FSH,LH), midluteal phase progesterone, Prolactin, TSH
   • transvaginal ultrasound
   • hysterosalpingography
   • detailed semen analysis

Exclusion Criteria

1. Age above 40

2. Smoking females

3. Obesity (BMI>30)

4. Women with any systemic or medical diseases leads to elevation of SAA as:

   1. Systemic lupus erythematosis
   2. Rheumatoid arthritis
   3. Sarcoidosis
   4. Diabetes Mellitus

5. Using hormonal contraception (for control group)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference between SAA level between cases and control.	1 day (once)

Secondary Outcome Measures

Name	Time	Method
Correlation between SAA level with other parameters in the hormonal profile (e.g., FSH, LH, E2).	1 day (once)

Trial Locations

Locations (1)

Ain Shams University Hospital; 🇪🇬 Cairo, Egypt