Pharmacokinetics of fluoride in saliva and urine after using no-rinse formula toothpaste
Phase 1
Recruiting
- Conditions
- Healthy men or women Healthy teeth and gumNo history of liver or kidney disease Normal salivary flow ratePharmacokinetics, No-rinse formula toothpaste, Saliva, Urine
- Registration Number
- TCTR20231104001
- Lead Sponsor
- Faculty of Dentistry, Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Healthy men or women
Healthy teeth and gum
No history of liver or kidney disease
Normal salivary flow rate
Exclusion Criteria
a. Edentulous (lacking natural teeth).
b. Liver or kidney disease
c. Allergic to any materials used in the study
d. Incapable of fasting for at least two hours
e. Took medications that might have affected their salivary flow rate
f. Infect SAR-CoV-2 or have a positive COVID-19 test within 5 days before the procedure
g. Drinking alcohol or smoking
g. Pregnancy
h. Unable to collect urine every 2 hours
i. Unwilling to participate in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fluoride levels in saliva and urine Baseline to 6 hours after brusing Using a calibrated ion-specific sensitive electrode
- Secondary Outcome Measures
Name Time Method /A N/A N/A