An evaluation of HLA, Phagocytic function and Trace elements in cases of Sinusitis, Invasive Fungal Sinusitis and Non-Invasive Fungal Sinusitis

AIIMS New Delhi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•This project will be conducted at AIIMS, New Delhi after approval from ethical committee. Total 200 patients will be recruited in study, out of 200, 50 patients will be included with diagnosis of sinusitis, 50 patients will be included with diagnosis of non-invasive fungal sinusitis and 50 patients will be included with diagnosis of invasive fungal sinusitis. For control, 50 blood samples will be collected from healthy individuals. All patients will be diagnosing by existing protocol in the department of Otolaryngology Head and Neck Surgery for sinonasal fungal disease. The current departmental practice for sinusitis is based on Rhinology society guidelines. Rhinology society proposed major and minor criteria to diagnose sinusitis. Fungal sinusitis is present with history of symptoms similar to sinusitis along with features of surrounding tissue invasion like orbit and brain. Invasive and non invasive fungal sinusitis is diagnosed on the basis of clinic radiological presentation and final conformation is based on histopathology. In non invasive fungal sinusitis radiology shows presence of heterogeneous characteristic mass in nose and paranasal sinuses with or without surrounding bone erosion. In comparison to invasive fungal sinusitis surrounding plane are maintained in non invasive fungal sinusitis.

发起方

AIIMS New Delhi