Changes in brain activities seen on functional magnetic resonance imaging (fMRI) during autobiographical tasks in patients with borderline personality disorder.

Not Applicable

Recruiting

• Conditions: Borderline personality disorder; Mental Health - Psychosis and personality disorders

• Registration Number: ACTRN12616000149460
• Lead Sponsor: Centre for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, Univerisity of Turin, Italy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-08
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients: diagnosis of borderline personality disorder.
Controls: subjects mached for age and gender without psychiatric disorders and neurological diseases.

Exclusion Criteria

Dementia, delirium, and other cognitive disorders; brain injuries; schizophrenia and other psychotic disorders; bipolar disorders; concurrent major depressive episode; substance abuse in the last two months; pharmacological treatments in the last three weeks; pregnant women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identity Disturbance Questionnaire (IDQ) total score to assess the relation between identity disturbance and alterations of brain functioning, measured during fMRI.[Identity Disturbance Questionnaire will be performed one week prior fMRI. During fMRI it will be done a continuous monitoring of brain activity for 30 seconds from time that each key-word is given and brain functioning will be also assessed during resting condition. ];Difference of change in brain activity during autobiographical task between patients and controls who have undergone fMRI will be registered. These data will be inserted into the Statistical Parametrical Mapping (SPM), a specific program to elaborate fMRI data.[fMRI assessment will be continuously done during active condition (for 30 seconds after the key-word presentation) and during resting condition (30 seconds after the fixation cross presentation).]

Secondary Outcome Measures

Name	Time	Method
Global symptoms assessed with the Clinical Global Impression Scale-Severity (CGI-S)[CGI-S will be performed one week before the fMRI];Specific borderline symptomatology measured with the Borderline Personality Disorder Severity Index (BPDSI)[BPDSI will be performed one week before the fMRI];Affective symptoms measured with the Hamilton Scale for Depression (HAM-D) [HAM-D will be performed one week before the fMRI];Interpersonal functioning measured with the Social and Occupational Functioning Assessing Scale (SOFAS)[SOFAS will be performed one week before the fMRI];Traumatic events assessed with The Childhood Trauma Questionnaire (CTQ)[CTQ will be performed one week before the fMRI];Anxious symtoms measured with the Hamilton Scale for Anxiety (HAM-A)[HAM-A will be performed one week before the fMRI]