Causes of Visual Loss in Retinal Disease

• Conditions: Uveitis; Scleritis
• Interventions: Drug: Immunosuppressive Agents

• Registration Number: NCT01613963
• Lead Sponsor: Royal Surrey County Hospital NHS Foundation Trust

Brief Summary

This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.

Detailed Description

This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2012-05-29
• Status Verified: 2012-06
• Study First Submitted QC: 2012-06-05
• Last Update Submitted: 2012-06-05
• Study First Posted: 2012-06-07
• Last Update Posted: 2012-06-07
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• patients with a diagnosis of ocular inflammation
• patients with at least 6 months of follow-up

Exclusion Criteria

• patients without a diagnosis of ocular inflammation
• patients with less than 6 months of follow-up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with ocular inflammation	Immunosuppressive Agents	Patients with ocular inflammation

Primary Outcome Measures

Name	Time	Method
Visual acuity at 5 years	5 years	Best-corrected visual acuity at 5 years

Secondary Outcome Measures

Name	Time	Method
Visual acuity at 10 years	10 years	Best corrected visual acuity at 10 years
Source of referral	Baseline	Categorised as A\&E/GP referral/Optician referral/Tertiary referral
Laterality	Baseline	Categorised as: Right eye/Left eye/Bilateral
Anatomical diagnosis	Baseline	Cateogorised as: Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis
Aetiological diagnosis	Baseline	Diagnosed as: Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant
Associated systemic disease	Baseline	Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis
Complications of disease and causes of visual loss at 5 years	5 years	Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony \& phthisis / other
Complications of disease and causes of visual loss at 10 years	10 years	Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony \& phthisis / other
Complications of disease and causes of visual loss	Up to 10 years	Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony \& phthisis / other
Treatment measures employed	Up to 10 years	Categorised into: Topical treatment / periocular steroid / intraocular steroid / intraocular other agent / Glaucoma treatment / systemic immunosuppressive agents
Complications of disease and treatment	Up to 10 years	Categorised into: 1. Local complications: Raised intraocular pressure / cataract / endophthalmitis / other; 2. Systemic complications: Diabetes / hypertension / cholesterol / liver function / bone density loss / other
Surgical procedures	Up to 10 years	List and dates of any intraocular surgery performed during the study
Burden of disease - appointments	Up to 10 years	Number of outpatient appointments over the course of the study
Burden of disease - outpatient procedures	Up to 10 years	Number of outpatient procedures over the course of the study
Burden of disease - inpatient procedures	Up to 10 years	Number of inpatient procedures over the course of the study
Blind registration	Up to 10 years	Year of any registration as partially sighted or blind

Trial Locations

Locations (2)

Moorfields Eye Hospital; 🇬🇧 London, United Kingdom

Royal Surrey County Hospital; 🇬🇧 Guildford, UK, United Kingdom