The efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever and complications in patients with dengue fever: a randomised, double blind, placebo controlled trial

niversity of Sri Jayewardenapura0 个研究点开始时间: 待定最近更新: 2024年8月20日

适应症

试验速览

暂无简介。

•1. Male and female patients aged between 18-60 years
•2. Dengue infection confirmed by a positive dengue NS1 antigen detection test (rapid immununochromatographic assays (rapid strip tests) at the out patient department)
•3. Duration of fever: <3 days
•4. No evidence of vascular leak.

•1. Known allergies to antihistamines
•2. Inability to take the drugs orally
•3. Known hepatic impairment defined as follows (all 3 criteria)
•History or clinical record of pre-existing liver disease
•Prolonged prothromin time of 4-6 seconds or more
•INR of >1.5
•4. Known renal impairment defined as:
•History or clinical record of pre-existing renal disease, predicted GFR <60 ml/min per 1.73 m2, hereditary kidney disease or recurrent or extensive nephrolithiasis
•5. Homelessness
•6. Known alcohol dependence or drug abuse
•7. Those with other pre-existing medical conditions that in the opinion of the investigators may impact the interpretation of the study.

发起方

niversity of Sri Jayewardenapura