A Multi-Omics Study of Vasospastic Angina

• Conditions: Vasospastic Angina

• Registration Number: NCT05282511
• Lead Sponsor: Tongji Hospital

Brief Summary

This is a observational study to identify the key factor associated with vasospastic angina and to explore the prognosis of the participants. The study will recruit 400 patients with vasospastic angina, 400 healthy controls and 400 patients with acute myocardial infarction. Next generation sequencing, metabolome and proteomics will be performed in these participants.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Status Verified: 2022-03
• Study First Submitted: 2022-03-07
• Study First Submitted QC: 2022-03-07
• Last Update Submitted: 2022-03-07
• Study First Posted: 2022-03-16
• Last Update Posted: 2022-03-16
• Primary Completion: 2022-12
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• 18 years of age or older
• diagnosed as vasospastic angina

Exclusion Criteria

• participate in any drug clinical trials within 3 months
• patients with life-threatening complications, or the researchers determined that the survival time of patients with no more than 1 years
• serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients)
• previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cardiovascular Death	up to 48 months	Death from cardiovascular causes and any unknown death unless there was another certain cause
Stroke	up to 48 months	A rapid onset of a new focal loss of neurologic function caused by an ischemic central nervous system event with residual symptoms lasting at least 24 hours from their onset or leading to death
Myocardial Infarction	up to 48 months	The definition of myocardial infarction was consistent with the Third Universal Definition of Myocardial Infarction.

Secondary Outcome Measures

Name	Time	Method
Recurrent angina	up to 48 months	Recurrent angina
Rehospitalization due to cardiovascular causes	up to 48 months	Rehospitalization due to cardiovascular causes

Trial Locations

Locations (1)

Tongji Hospital; 🇨🇳 Wuhan, Hubei, China