Identification of the Key Factors Increasing the Risk of Vasospastic Angina Based on Multi-omics.
试验速览
- 阶段
- 不适用
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Cardiovascular Death
研究概览
简要总结
This is a observational study to identify the key factor associated with vasospastic angina and to explore the prognosis of the participants. The study will recruit 400 patients with vasospastic angina, 400 healthy controls and 400 patients with acute myocardial infarction. Next generation sequencing, metabolome and proteomics will be performed in these participants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age or older
- •diagnosed as vasospastic angina
排除标准
- •participate in any drug clinical trials within 3 months
- •patients with life-threatening complications, or the researchers determined that the survival time of patients with no more than 1 years
- •serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients)
- •previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix)
结局指标
主要结局
Cardiovascular Death
时间窗: up to 48 months
Death from cardiovascular causes and any unknown death unless there was another certain cause
Stroke
时间窗: up to 48 months
A rapid onset of a new focal loss of neurologic function caused by an ischemic central nervous system event with residual symptoms lasting at least 24 hours from their onset or leading to death
Myocardial Infarction
时间窗: up to 48 months
The definition of myocardial infarction was consistent with the Third Universal Definition of Myocardial Infarction.
次要结局
- Recurrent angina(up to 48 months)
- Rehospitalization due to cardiovascular causes(up to 48 months)