Short course normal saline infusion in contrast-enhanced computed tomography for contrast-associated acute kidney injury (CA-AKI) prevention in CKD G3b patients: An open-label randomized controlled trial and incidence of subclinical CA-AKI using kidney biomarkers
Phase 3
- Conditions
- There is a controversy to CA-AKI prevention in patients with elevated risk (CKD G3b) with short course normal saline infusion protocol with contrast-enhanced CT. Prevention is definitely useful for prevention of CA-AKI in CKD G4.contrast associated acute kidney injury,
- Registration Number
- TCTR20221006001
- Lead Sponsor
- ational Research Council of Thailand (NRCT)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 192
Inclusion Criteria
CKD stage 3b that undergoing contrast-enhanced CT in Naresuan University hospital
Exclusion Criteria
Uncontrolled congestive heart failure
Cardiomyopathy with EF < 30%
Currently AKI from other causes
Septic shock or hemodynamically unstable
Pregnancy
Refuse inform consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Contrast associated acute kidney injury 48 h to 7 d serum creatinine,Receiver operating characteristic of contrast associated acute kidney injury 48 h to 7 d urinary neutrophil gelatinase-associated lipocalin, urinary liver-type fatty acid binding protein
- Secondary Outcome Measures
Name Time Method subacute contrast associated acute kidney injury 48 h to 7 d urinary neutrophil gelatinase-associated lipocalin, urinary liver-type fatty acid binding protein ,Receiver operating characteristic of contrast associated acute kidney injury 48 h to 7 d urinary neutrophil gelatinase-associated lipocalin, urinary liver-type fatty acid binding protein