Effect of intermittent normal saline bolus during hemodialysis on adequacy of dialysis
Phase 4
- Conditions
- Hemodialysis.Z49.1
- Registration Number
- IRCT2015100324303N1
- Lead Sponsor
- Vice Chancellor for Research and Innovation, Golestan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Inclusion Criteria: Patients with end-stage renal disease treated with maintenance hemodialysis for at least six months; Age above 18 years old; Willingness to participate in the study; On 3 times per week, 4-hours long maintenance hemodialysis; Arteriovenous Fistula or Graft access type; Receives 5000 units of unfractionated heparin during each session of hemodialysis;Hemoglobin concentration 9 to 14 grams per deciliter.
Exclusion Criteria
Having acute debilitating disease (cardiovascular, hypertension, cancer and acute infection); Having systolic blood pressure below 90 and above 160 mm Hg.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Adequacy of Hemodialysis (KT/V) and Urea Reduction Ratio (URR). Timepoint: At first and third session of hemodialysis. After a one-week washout time, again at the first and third session of hemodialysis. Method of measurement: Pre and post dialysis serum urea and calculation of URR and KT/V using formula recommended by Ministry of Health and Medical Education.
- Secondary Outcome Measures
Name Time Method Clot formation in extracorporeal tubing. Timepoint: At the end of each hemodialysis sessions. Method of measurement: By direct observation and grading.