Evaluation Of Intralesional Platelet-Rich Fibrin Versus Intralesional Vitamin D In Treatment Of Common Warts
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- treatment of common wart by PRF injection ( Mild response: < 50% reduction in lesion size , Moderate response: ≥ 50% reduction in lesion size , to measure the change in lesion size , is the patient satisfied or not )
研究概览
简要总结
this study aims to compare the efficacy and safety of platelet rich fibrin injection versus intralesional vitamin D injection in the treatmentof common warts. PRF, as an autologous biological material , may enhance tissue regeneration and immune response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age more than or equal to 18 years
- •Clinically and dermoscopically confirmed Common warts of both sex
- •patient not receiving previous treatment at least one month before recruitment in our study
- •Single or multiple lesions suitable for injection.
排除标准
- •Chronic Systemic desise (DM , HTN , Autoimmune , immunosuppressive disorders eg , lupus , renal or hepatic failure ) or Hematologic Conditions (anemia : hemoglobin level below 10 g/dl , thrombocytopenia : platelet count below 150,000 /µL ) Infectious Diseases , Local bacterial or fungal infection at the lesions .
- •Pregnancy, Lactation , patients who has hypersensitivity of vitamin D .
研究组 & 干预措施
group 1 PRF injection
干预措施: PRF group (Biological)
group 2 vitamin D injection
干预措施: Vitamin D (Drug)
结局指标
主要结局
treatment of common wart by PRF injection ( Mild response: < 50% reduction in lesion size , Moderate response: ≥ 50% reduction in lesion size , to measure the change in lesion size , is the patient satisfied or not )
时间窗: 1 session every 2 weeks for 3 months
treatment of common wart by intralesional injection of PRF
changes in common warts after treatment by PRF (measuring complete clearance and recurrence of the lesions ,asking about patient satisfaction )
时间窗: 6 months after the last session
次要结局
未报告次要终点
研究者
Bassma Alaaeldin Mohamed
Dermatology , Venerology and Andrology Resident at Sohag University Hospital
Sohag University