Evaluation Of Intralesional Platelet-Rich Fibrin Versus Intralesional Vitamin D In Treatment Of Common Warts
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Sohag University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- treatment of common wart by PRF injection ( Mild response: < 50% reduction in lesion size , Moderate response: ≥ 50% reduction in lesion size , to measure the change in lesion size , is the patient satisfied or not )
Overview
Brief Summary
this study aims to compare the efficacy and safety of platelet rich fibrin injection versus intralesional vitamin D injection in the treatmentof common warts. PRF, as an autologous biological material , may enhance tissue regeneration and immune response.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •\- Age more than or equal to 18 years
- •Clinically and dermoscopically confirmed Common warts of both sex
- •patient not receiving previous treatment at least one month before recruitment in our study
- •Single or multiple lesions suitable for injection.
Exclusion Criteria
- •Chronic Systemic desise (DM , HTN , Autoimmune , immunosuppressive disorders eg , lupus , renal or hepatic failure ) or Hematologic Conditions (anemia : hemoglobin level below 10 g/dl , thrombocytopenia : platelet count below 150,000 /µL ) Infectious Diseases , Local bacterial or fungal infection at the lesions .
- •Pregnancy, Lactation , patients who has hypersensitivity of vitamin D .
Arms & Interventions
group 1 PRF injection
Intervention: PRF group (Biological)
group 2 vitamin D injection
Intervention: Vitamin D (Drug)
Outcomes
Primary Outcomes
treatment of common wart by PRF injection ( Mild response: < 50% reduction in lesion size , Moderate response: ≥ 50% reduction in lesion size , to measure the change in lesion size , is the patient satisfied or not )
Time Frame: 1 session every 2 weeks for 3 months
treatment of common wart by intralesional injection of PRF
changes in common warts after treatment by PRF (measuring complete clearance and recurrence of the lesions ,asking about patient satisfaction )
Time Frame: 6 months after the last session
Secondary Outcomes
No secondary outcomes reported
Investigators
Bassma Alaaeldin Mohamed
Dermatology , Venerology and Andrology Resident at Sohag University Hospital
Sohag University