Salt and its effects on endothelial function in patients with type two diabetes

Not Applicable

Completed

• Conditions: Diabetes; Endothelial Function; Sympathetic nervous system activity; Metabolic and Endocrine - Diabetes; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Neurological - Other neurological disorders

• Registration Number: ACTRN12613000127707
• Lead Sponsor: Dr Elif Ilhan Ekinci, Director of Diabetes

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-02-01
• Study Completion: 2019-11-18
• Last Update Posted: 16 February 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Blood Pressure <150/80
Body Mass Index matched
2 out of 3 24 hour urine collections <150mmol/24h
35 patients will be recruited into the Type Two Diabetes arm and 35 non-diabetic patients will be recruited into the control arm.

Exclusion Criteria

Other active significant medical problems, including clinical autonomic neuropathy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patients with Type 2 diabetes (Cases) with habitual salt intake in the lowest tertile (<150mmol/24h), have increased baseline Sympathetic Nervous System (SNS) activity and increased endothelial dysfunction compared to Controls. [During baseline visit, week three and week nine of the trial, the SNS will be measured by muscle sympathetic Muscle Sympathetic Nerve Activity (MSNA) and by Pulse Amplitude Tonometry (EndoPAT). For endothelial dysfunction, this will be measured at baseline and the start of week three, week six and week nine. ];Salt loading (100mmol/24h over 3 weeks) will reduce SNS activity and improve endothelial function in Cases, not Controls. <br>a.Reduction in SNS activity will be measured by Muscle Sympathetic Nerve Activity (MSNA).<br>b.Improved endothelial function will be measured by Pulse Amplitude Tonometry (EndoPAT).<br>c.Improved endothelial function will be measured by endothelial microparticles (EMP).<br>[Nine weeks]

Secondary Outcome Measures

Name	Time	Method
Il[NIl]