A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
- Conditions
- Non-Small Cell Lung CancerKRAS G12C Lung Cancer
- Interventions
- Registration Number
- NCT06497556
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
The purpose of this study is to assess the safety and efficacy of divarasib compared to locally approved KRAS G12C inhibitors (sotorasib or adagrasib) in participants with KRAS G12C-positive (KRAS G12C +) advanced or metastatic non-small cell lung cancer (NSCLC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 320
- Unequivocal histologically or cytologically confirmed diagnosis of metastatic or locally advanced NSCLC not amenable to treatment with surgical resection or combined chemoradiation
- Disease progression during or after treatment with at least one prior systemic therapy but no more than three lines of prior systemic therapy in the advanced or metastatic setting
- Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
- Documentation of the presence of a KRAS G12C mutation
- Availability of a representative formalin-fixed, paraffin-embedded (FFPE) tumor specimen in a paraffin block (preferred) or 10-15 (15 preferred) unstained, freshly cut, serial slides with an associated pathology report
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Life expectancy of >= 12 weeks
- Known hypersensitivity to any of the components of divarasib, or sotorasib or adagrasib
- Malabsorption syndrome or other condition that would interfere with enteral absorption
- Known concomitant second oncogenic driver
- Mixed small-cell lung cancer or large cell neuroendocrine histology
- Known and untreated, or active central nervous system (CNS) metastases
- Leptomeningeal disease or carcinomatous meningitis
- Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures biweekly or more frequently
- Any infection that, in the opinion of the investigator, could impact patient safety, or treatment with therapeutic oral or IV antibiotics within 14 days prior to Day 1 of Cycle 1
- Prior treatment with any KRAS G12C inhibitor or pan-KRAS/RAS inhibitor
- More than 30 Gy of radiotherapy to the lung within 6 months of randomization
- Uncontrolled tumor-related pain
- Unresolved toxicities from prior anticancer therapy
- History of malignancy within 5 years prior to screening, with the exception of the cancer under investigation in this study and malignancies with a negligible risk of metastasis or death (e.g., 5-year OS rate >90%), such as adequately treated carcinoma in situ of the cervix, nonmelanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or Stage I uterine cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Divarasib Divarasib Participants will receive divarasib orally, once daily (QD). KRAS G12C inhibitor Sotorasib Participants will receive Sotorasib orally QD or adagrasib orally twice a day (BID) KRAS G12C inhibitor Adagrasib Participants will receive Sotorasib orally QD or adagrasib orally twice a day (BID)
- Primary Outcome Measures
Name Time Method Progression-Free Survival (PFS) Up to approximately 4 years PFS is defined as the time from randomization to the first occurrence of disease progression, as determined by blinded independent central review (BICR) according to RECIST v1.1, or death from any cause (whichever occurs first)
- Secondary Outcome Measures
Name Time Method TTCD on the Chest Pain Scale of the QLQ-LC13 Scales Up to approximately 4 years Overall Survival (OS) Up to approximately 4 years OS is defined as the time from randomization to death from any cause
Objective Response Up to approximately 4 years Objective response is defined as complete response (CR) or partial response (PR) as determined by BICR according to RECIST v1.1
Time to Confirmed Deterioration (TTCD) on the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Dyspnea Item and Physical Functioning Scale Baseline up to approximately 4 years TTCD on the EORTC Quality-of-Life Questionnaire-Supplemental Lung Cancer Module (QLQ-LC13) Cough Scale Baseline up to approximately 4 years Duration of Response (DOR) Up to approximately 4 years DOR is defined as the time from the first occurrence of a documented objective response to disease progression, as determined by BICR according to RECIST v1.1, or death from any cause (whichever occurs first)
Percentage of Participants with Adverse Events (AEs) Up to approximately 4 years Number of Participants Reporting Presence, Frequency, Severity, and/or Degree of Interference with Daily Function of Symptomatic Treatment Toxicities Assessed by NCI Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE) Up to approximately 4 years Change from Baseline in Diarrhea, Nausea, Vomiting, Anorexia, Alopecia, Dyspnea, Cough, Constipation, Myalgia, Headache, and Rash/Acne as Assessed Through use of the NCI PRO-CTCAE Baseline up to approximately 4 years Frequency of Participants' Response of the Degree they are Troubled with Treatment Symptoms, as Assessed Through use of the single-item EORTC Item List (IL46) Up to approximately 4 years Change from Baseline in Cough, Chest Pain, Dyspnea, Physical and Role Functioning, and Global Health Status score/Quality of Life Score (GHS/QoL) at Each Timepoint as Assessed Through use of the EORTC QLQ-LC13 and QLQ-C30 Baseline up to approximately 4 years TTCD on the EORTC QLQ-C30 Role Functioning and GHS/QoL scales Up to approximately 4 years
Trial Locations
- Locations (243)
Amphia Ziekenhuis
🇳🇱Breda, Netherlands
Dolno?L?Skie Centrum Onkologii, Pulmonologii I Hematologii
🇵🇱Wroc?aw, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Hospital Vall Hebron
🇪🇸Barcelona, Spain
Gävle Sjukhus
🇸🇪Gävle, Sweden
Hsin-Chu Branch of National Taiwan University Hospital
🇨🇳Hsinchu City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
CHRU Brest
🇫🇷Brest, France
Regionshospitalet Gødstrup
🇩🇰Herning, Denmark
Hia Sainte Anne
🇫🇷Toulon, France
Chu Toulouse
🇫🇷Bron, France
Evangelische Lungenklinik Berlin
🇩🇪Berlin, Germany
Hopital Louis Pradel
🇫🇷Bron, France
CHRU Lille
🇫🇷Lille, France
New York Cancer & Blood Specialists
🇺🇸Bronx, New York, United States
Sanatorio Parque S.A.
🇦🇷Rosario, Argentina
Hopital Tenon
🇫🇷Paris, France
Renown Regional Medical Center Hospital
🇺🇸Reno, Nevada, United States
Turku Uni Central Hospital
🇫🇮Turku, Finland
Kinghorn Cancer Centre
🇦🇺Darlinghurst, New South Wales, Australia
CHU Angers
🇫🇷Angers, France
CHU Bordeaux
🇫🇷Pessac, France
Banner Health MD Anderson AZ
🇺🇸Gilbert, Arizona, United States
University of Arkansas For Medical Sciences
🇺🇸Little Rock, Arkansas, United States
UCLA Hematology / Oncology Clinic
🇺🇸Los Angeles, California, United States
Community Clinical Trials
🇺🇸Orange, California, United States
Centro Oncologico Korben
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
University of California, San Francisco
🇺🇸San Francisco, California, United States
UC Health Oncology Research
🇺🇸Colorado Springs, Colorado, United States
Yale Cancer Center
🇺🇸New Haven, Connecticut, United States
Bay Pines Foundation Inc
🇺🇸Bay Pines, Florida, United States
Florida Cancer Specialists
🇺🇸West Palm Beach, Florida, United States
University of Miami
🇺🇸Miami, Florida, United States
Cancer Specialists of North Florida
🇺🇸Saint Augustine, Florida, United States
Florida Cancer Specialists.
🇺🇸Saint Petersburg, Florida, United States
University Cancer & Blood Center, LLC
🇺🇸Athens, Georgia, United States
Summit Cancer Care PC
🇺🇸Savannah, Georgia, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
IU Health Ball Memorial Hospital
🇺🇸Muncie, Indiana, United States
Mission Cancer + Blood - IMMC
🇺🇸Waukee, Iowa, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
Norton Cancer Institute- Poplar
🇺🇸Louisville, Kentucky, United States
VA Shreveport Healthcare System
🇺🇸Shreveport, Louisiana, United States
New England Cancer Specialists
🇺🇸Scarborough, Maine, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Dana Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Henry Ford Health System;Clinical Trials Office
🇺🇸Detroit, Michigan, United States
Cancer and Hematology Centers of Western Michigan
🇺🇸Grand Rapids, Michigan, United States
Nebraska Methodist Estabrook Cancer Center
🇺🇸Omaha, Nebraska, United States
CH de Saint Quentin
🇫🇷Saint Quentin, France
New York Cancer & Blood Specialists - New Hyde Park
🇺🇸New Hyde Park, New York, United States
New York Cancer and Blood Specialists-Central Park Hematology & Oncology
🇺🇸New York, New York, United States
Mount SInai Medical Center
🇺🇸New York, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
🇺🇸Shirley, New York, United States
University of North Carolina At Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
East Carolina University
🇺🇸Greenville, North Carolina, United States
Firsthealth of The Carolinas
🇺🇸Pinehurst, North Carolina, United States
Ohio State University Comprehensive Cancer Center
🇺🇸Columbus, Ohio, United States
SCRI Mark H. Zangmeister Center
🇺🇸Columbus, Ohio, United States
Taylor Cancer Research Center
🇺🇸Maumee, Ohio, United States
Oncology Associates of Oregon, P.C
🇺🇸Eugene, Oregon, United States
Oregon Health & Science University
🇺🇸Portland, Oregon, United States
Allegheny Cancer Center
🇺🇸Pittsburgh, Pennsylvania, United States
Gibbs Cancer Center & Research Institute
🇺🇸Spartanburg, South Carolina, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Tennessee Oncology, PLLC - Chattanooga
🇺🇸Chattanooga, Tennessee, United States
Baptist Clinical Research Institute
🇺🇸Memphis, Tennessee, United States
Tennessee Oncology
🇺🇸Nashville, Tennessee, United States
JPS Health Network
🇺🇸Fort Worth, Texas, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Virginia Commonwealth University - Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Hospital Britanico
🇦🇷Buenos Aires, Argentina
Chru de Strasbourg
🇫🇷Strasbourg, France
Clinica Adventista Belgrano
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Clinica Onconeo
🇧🇷Campo Grande, Mato Grosso Do Sul, Brazil
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
GenesisCare North Shore
🇦🇺St Leonards, New South Wales, Australia
Sunshine Coast University Hospital
🇦🇺Birtinya, Queensland, Australia
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, South Australia, Australia
Peter Maccallum Cancer Centre
🇦🇺Melbourne, Victoria, Australia
Klinik Penzing
🇦🇹Wien, Austria
Institut für Lungenforschung Wien
🇦🇹Wien, Austria
Krankenhaus Nord - Klinik Floridsdorf
🇦🇹Wien, Austria
AZORG Campus Aalst-Moorselbaan
🇧🇪Aalst, Belgium
UZ Brussel
🇧🇪Brussel, Belgium
Cliniques Universitaires St-Luc
🇧🇪Bruxelles, Belgium
UZ Antwerpen
🇧🇪Edegem, Belgium
Jessa Zkh (Campus Virga Jesse)
🇧🇪Hasselt, Belgium
CHU Sart-Tilman
🇧🇪Liège, Belgium
CHU UCL Mont-Godinne
🇧🇪Mont-godinne, Belgium
AZ Delta (Campus Rumbeke)
🇧🇪Roeselare, Belgium
Vitaz
🇧🇪Sint Niklaas, Belgium
Sint Augustinus Wilrijk
🇧🇪Wilrijk, Belgium
Hospital Sao Rafael - HSR
🇧🇷Salvador, Bahia, Brazil
Hospital Brasilia
🇧🇷Brasilia, Distrito Federal, Brazil
Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Nossa Senhora da Conceicao
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital de Cancer de Barretos
🇧🇷Barretos, São Paulo, Brazil
Hospital de Base de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, São Paulo, Brazil
Hospital Sírio-Libanês
🇧🇷Sao Paulo, São Paulo, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, São Paulo, Brazil
Oncoclinicas Rio de Janeiro S.A.
🇧🇷Rio de Janeiro, Brazil
William Osler Health Centre - Brampton Civic Hospital
🇨🇦Brampton, Ontario, Canada
Princess Margaret Cancer Center
🇨🇦Toronto, Ontario, Canada
Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
Aarhus Universitetshospital
🇩🇰Aarhus N, Denmark
Herlev Hospital
🇩🇰Herlev, Denmark
Helsinki University Central Hospital
🇫🇮Helsinki, Finland
Kuopio Uni Hospital
🇫🇮Kuopio, Finland
Centre Leon Berard
🇫🇷Lyon, France
CHU Montpellier
🇫🇷Montpellier, France
Centre Antoine Lacassagne Centre Régional de Lutte Contre Le Cancer
🇫🇷Nice, France
Charité Universitätsmedizin Berlin, Med Klinik Infekto und Pneumo
🇩🇪Berlin, Germany
Helios Klinikum Emil von Behring GmbH
🇩🇪Berlin, Germany
Klinikum Braunschweig
🇩🇪Braunschweig, Germany
KEM/Evang. Kliniken Essen Mitte gGmbH
🇩🇪Essen, Germany
Universitätsklinikum Essen
🇩🇪Essen, Germany
Klinikum Esslingen
🇩🇪Esslingen, Germany
Asklepios Fachkliniken GmbH
🇩🇪Gauting, Germany
LungenClinic Großhansdorf GmbH
🇩🇪Großhansdorf, Germany
Krankenhaus Martha-Maria Halle-Doelau gGmbH
🇩🇪Halle, Germany
Thoraxklinik Heidelberg gGmbH
🇩🇪Heidelberg, Germany
Lungenklinik Hemer
🇩🇪Hemer, Germany
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Universität Des Saarlandes
🇩🇪Homburg, Germany
Lungenfachklinik Immenhausen
🇩🇪Immenhausen, Germany
Uniklinik Schleswig-Holstein
🇩🇪Kiel, Germany
Klinikum Koeln-Merheim
🇩🇪Köln, Germany
SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein
🇩🇪Löwenstein, Germany
Universitätsklinikum Schleswig-Holstein
🇩🇪Lübeck, Germany
Universität Mannheim
🇩🇪Mannheim, Germany
Klinikum Bogenhausen
🇩🇪München, Germany
Universitätsklinikum Münster, Medizinische Klinik A, Translationale Onkologie
🇩🇪Münster, Germany
Pius Hospital Oldenburg
🇩🇪Oldenburg, Germany
Universitätsklinikum Regensburg
🇩🇪Regensburg, Germany
Klinikum Würzburg Mitte gGmbH
🇩🇪Würzburg, Germany
Uoa Sotiria Hospital
🇬🇷Athens, Greece
Errikos Dynan Hospital
🇬🇷Athens, Greece
Metropolitan Hospital Fourth Oncology Clinic
🇬🇷Faliro, Greece
University Hospital of Larissa
🇬🇷Larissa, Greece
Theageneio Hospital
🇬🇷Thessaloniki, Greece
Ag. Loukas Hospital
🇬🇷Thessaloniki, Greece
Hong Kong Integrated Oncology Centre
🇭🇰Hong Kong, Hong Kong
Tuen Mun Hospital
🇭🇰Hong Kong, Hong Kong
Prince of Wales Hosp
🇭🇰Shatin, Hong Kong
Az. Osp. Pugliese Ciaccio
🇮🇹Catanzaro, Calabria, Italy
AZ.Osp S. Orsola ? Malpighi-Reparto di Oncologia Medica
🇮🇹Bologna, Emilia-Romagna, Italy
A.O. Universitaria Di Parma
🇮🇹Parma, Emilia-Romagna, Italy
AUSL della Romagna
🇮🇹Ravenna, Emilia-Romagna, Italy
Azienda Sanitaria Universitaria Friuli Centrale ? PO Universitario Santa Maria della Misericordia
🇮🇹Udine, Friuli-Venezia Giulia, Italy
IRCCS Istituto Regina Elena (IFO)
🇮🇹Roma, Lazio, Italy
Ospedale Policlinico San Martino
🇮🇹Genova, Liguria, Italy
Asst Papa Giovanni XXIII
🇮🇹Bergamo, Lombardia, Italy
IRCCS Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Lombardia, Italy
A.O.U. Maggiore della Carità
🇮🇹Novara, Piemonte, Italy
Irccs Ist. Tumori Giovanni Paolo Ii
🇮🇹Bari, Puglia, Italy
Ospedale Civile SS Annunziata
🇮🇹Sassari, Sardegna, Italy
AO Ospedali Riuniti Villa Sofia-Cervello-Presidio Ospedaliero Cervello
🇮🇹Palermo, Sicilia, Italy
Azienda Ospedaliero-Universitaria Careggi
🇮🇹Firenze, Toscana, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Toscana, Italy
IRCCS Istituto Oncologico Veneto (IOV)
🇮🇹Padova, Veneto, Italy
Shikoku Cancer Center
🇯🇵Ehime, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Japan
Hokkaido University Hospital
🇯🇵Hokkaido, Japan
Sendai Kousei Hospital
🇯🇵Miyagi, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Kindai University Hospital
🇯🇵Osaka, Japan
Shizuoka Cancer Center
🇯🇵Shizuoka, Japan
National Cancer Center Hospital
🇯🇵Tokyo, Japan
The Cancer Institute Hospital of JFCR
🇯🇵Tokyo, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Chungbuk National University Hospital
🇰🇷Cheongju-si, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Keimyung University Dongsan Medical Center
🇰🇷Daegu, Korea, Republic of
St. Vincent's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Pusan National University Yangsan Hospital
🇰🇷Gyeongsangnam-do, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Chonnam National University Hwasun Hospital
🇰🇷Jeollanam-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Centro de Infusion E Investigacion Oncologia de Saltillo Sc
🇲🇽Saltillo, Coahuila, Mexico
Hospital Civil de Guadalajara Fray Antonio Alcalde
🇲🇽Guadalajara, Jalisco, Mexico
Clínica Integral Internacional de Oncología S de RL de CV
🇲🇽Heroica Puebla de Zaragoza, Puebla, Mexico
PanAmerican Clinical Research, Querétaro
🇲🇽Santiago de Querétaro, Queretaro, Mexico
ARKE Estudios Clínicos S.A. de C.V.
🇲🇽Ciudad de México, Mexico
Jeroen Bosch Ziekenhuis
🇳🇱'S Hertogenbosch, Netherlands
Ziekenhuis Rijnstate
🇳🇱Arnhem, Netherlands
Ziekenhuis St. Jansdal
🇳🇱Harderwijk, Netherlands
Medisch Centrum Haaglanden, locatie Antoniushove
🇳🇱Leidschendam, Netherlands
Isala
🇳🇱Zwolle, Netherlands
Instytut "Centrum Zdrowia Matki Polki"
🇵🇱?ód?, Poland
Kujawsko-Pomorskie Centrum Pulmonologii
🇵🇱Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
🇵🇱Gdansk, Poland
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II
🇵🇱Kraków, Poland
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
🇵🇱Lublin, Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
🇵🇱Olsztyn, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
🇵🇱Poznan, Poland
Radomskie Centrum Onkologii
🇵🇱Radom, Poland
Instytut Gruzlicy I Chorob Pluc
🇵🇱Warszawa, Poland
Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad
🇵🇱Warszawa, Poland
CHUC - Unidade de Pneumologia Oncológica
🇵🇹Coimbra, Portugal
Centro Clinico Champalimaud
🇵🇹Lisboa, Portugal
Centro Hospitalar do Porto ? Hospital de Santo António
🇵🇹Porto, Portugal
IPO do Porto
🇵🇹Porto, Portugal
National Cancer Centre
🇸🇬Singapore, Singapore
Curie Oncology (Farrer)
🇸🇬Singapore, Singapore
Institut Catala d Oncologia Hospitalet
🇪🇸Hospitalet de Llobregat, Barcelona, Spain
Hospital Nuestra Senora de Valme
🇪🇸Seville, Sevilla, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Spain
Hospital Universitario la Fe
🇪🇸Valencia, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Chung Shan Medical University Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation - Linkou
🇨🇳Taoyuan, Taiwan
Vajira Hospital
🇹🇭Bangkok, Thailand
Siriraj Hospital - Chulabhorn Bone Marrow Transplant Centre
🇹🇭Bangkok, Thailand
Srinagarind Hospital
🇹🇭Khon Kaen, Thailand
Songklanagarind Hospital
🇹🇭Songkhla, Thailand
Blackpool Victoria Hospital
🇬🇧Blackpool, United Kingdom
Addenbrooke's Hospital
🇬🇧Cambridge, United Kingdom
Velindre NHS Trust - Velindre Cancer Centre
🇬🇧Cardiff, United Kingdom
Castle Hill Hospital
🇬🇧Cottingham, United Kingdom
Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
St James University Hospital
🇬🇧Leeds, United Kingdom
Guy's Hospital - Cancer Centre
🇬🇧London, United Kingdom
Royal Marsden Hospital - London
🇬🇧London, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Nottingham City Hospital
🇬🇧Nottingham, United Kingdom
University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital
🇬🇧Stoke-On-Trent, United Kingdom
Royal Marsden Hospital (Sutton)
🇬🇧Sutton, United Kingdom
Torbay Hospital
🇬🇧Torquay, United Kingdom