The Relationship Between NK Cell and Graves' Disease
- Conditions
- Graves Disease
- Registration Number
- NCT04135573
- Lead Sponsor
- Shandong Provincial Hospital
- Brief Summary
Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- New GD patients without any treatment
- Aged of 18 to 75 years old
- Pregnant or lactating woman;
- Known autoimmune disease;
- Receiving psychotropic or hormonal drugs;
- Taking drugs that affect the body's immune function;
- Obviously poor compliance.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number and function of NK cells changes of hyperthyroidism measured after 2 years of follow-up Flow cytometry used to measure the related changes of NK cells in hyperthyroidism
- Secondary Outcome Measures
Name Time Method Changes in serum levels measured after 2 years of follow-up Detection of related cytokines by ELISA
Trial Locations
- Locations (1)
Shandong Provincial Hospital
🇨🇳Jinan, Shandong, China