Mechanism of NK Cell Disfunction in Graves' Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- The number and function of NK cells changes of hyperthyroidism
研究概览
简要总结
Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •New GD patients without any treatment
- •Aged of 18 to 75 years old
排除标准
- •Pregnant or lactating woman;
- •Known autoimmune disease;
- •Receiving psychotropic or hormonal drugs;
- •Taking drugs that affect the body's immune function;
- •Obviously poor compliance.
结局指标
主要结局
The number and function of NK cells changes of hyperthyroidism
时间窗: measured after 2 years of follow-up
Flow cytometry used to measure the related changes of NK cells in hyperthyroidism
次要结局
- Changes in serum levels(measured after 2 years of follow-up)
研究者
Hai-qing Zhang
professor
Shandong Provincial Hospital