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临床试验/NCT06812650
NCT06812650已完成不适用

Effects of Diaphragmatic Breathing and Relaxation Exercises in Patients With Gastroesophageal Reflux

Karabuk University1 个研究点 分布在 1 个国家目标入组 68 人开始时间: 2025年2月3日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
68
试验地点
1
主要终点
Gastroesophageal Reflux Disease Questionnaire

研究概览

简要总结

The aim of this study was to examine the effects of diaphragmatic breathing exercises combined with relaxation exercises on patient-reported reflux symptoms, quality of life, anxiety, and depression levels in patients diagnosed with gastroesophageal reflux.

详细描述

Gastroesophageal reflux disease is a pathological condition in which various symptoms and/or complications occur as a result of the escape of stomach contents into the esophagus, oral cavity, or lungs. Gastroesophageal reflux disease is largely associated with various respiratory diseases such as chronic cough, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma. Accordingly, respiratory function deterioration may be observed in spirometric measurements. Increased symptom burden in gastroesophageal reflux patients has been associated with poor quality of life, sleep disturbances, and decreased physical function and productivity. However, increased anxiety and depression levels in patients are also closely related to reflux symptoms.At the esophagogastric junction, the lower esophageal sphincter and the surrounding crura of the diaphragm constitute an important part of the protective mechanism against reflux. The crural diaphragm, which contracts during inspiration, acts as an additional external sphincter. Since the crural diaphragm is a striated muscle structure, it is possible to improve its function with exercise. Eherer et al. (2012) examined the effects of diaphragmatic breathing exercises performed for 30 minutes per day for 4 weeks on pH levels, quality of life, and medication use in patients with non-erosive reflux. As a result of the study, they found that quality of life increased and acid exposure decreased.The recurrence rate and maintenance treatment requirement after treatment are high in reflux patients. Proton pump inhibitor drugs commonly used in treatment may have various side effects in the long term. Although the diaphragm muscle is an important part of the protective mechanism against reflux, there are few studies investigating the effects of applications targeting this muscle on reflux.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Individuals who do not have cardiopulmonary, mental, connective tissue, metabolic, or other diseases that may prevent exercise
  • Individuals who do not have body mass index >35 or <18
  • Individuals who are not addicted to alcohol or cigarettes
  • Individuals who are between the ages of 18 and 65
  • Individuals who are diagnosed with non-erosive reflux will be included in the study.

排除标准

  • Individuals with a history of gastrointestinal surgery
  • Individuals who are pregnant or breastfeeding
  • Individuals who have hiatal hernia

结局指标

主要结局

Gastroesophageal Reflux Disease Questionnaire

时间窗: Eight weeks

Reflux symptoms will be assessed with the Gastroesophageal Reflux Disease Questionnaire. The frequency of 6 questions regarding heartburn, regurgitation, dyspepsia, nausea, need for medication, and sleep disturbances in the last 7 days are scored. The total score can range from 0-18.

Gastroesophageal Reflux Disease- Quality of Life

时间窗: Eight weeks

The scale aims to measure how regurgitation and pyrosis symptoms have affected the patient's daily life in the last 7 days. It consists of 16 questions under 4 main headings: daily activity, treatment effect, diet and psychological well-being. It is evaluated with a five-point Likert-type scale. A low total score indicates that the quality of life has also decreased.

次要结局

  • The Hospital Anxiety and Depression Scale(Eight weeks)

研究者

发起方
Karabuk University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Tarik Ozmen

Professor

Karabuk University

研究点 (1)

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