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Microvascular Ocular Changes of Systemic Lupus Erythematous

Recruiting
Conditions
Eye Manifestations
Lupus Erythematosus, Systemic
Registration Number
NCT05863689
Lead Sponsor
Universidade do Porto
Brief Summary

The goal of this observational study is to to assess the ocular microvascular status of SLE patients with inactive disease and without ocular involvement. The main questions it aims to answer are:

* the choroidal vascular status and thickness in SLE

* the retinal macular microvascular status and structure in SLE

Participants will be assessed with Spectral Domain Optical Coherence Tomography (SD-OCT). Researchers will compare SLE patients with healthy controls matched for age and sex.

Detailed Description

The investigators will perform a cross-sectional evaluation of 25 SLE patients and 25 healthy controls matched for sex and age, using a Spectral Domain Optical Coherence Tomography (SD-OCT) with Enhanced Depth Imaging for choroidal assessment and with Angiography module to assess the retinal and choriocapillaris vasculature. Processing of image with external software will be performed to calculate the main outcomes: retinal vessel density, foveal avascular zone parameters and the choroidal vascular index.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
50
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Measurement of choroidal vascular index6 months

Comparison of choroidal vascular index between SLE patients and healthy controls using OCT with Enhance Depth Imaging

Measurement of retinal vessel density6 months

Comparison of retinal vessel density of superficial and deep plexuses between SLE patients and healthy controls using OCT Angiography.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Centro Hospitalar Universitário de Santo António

🇵🇹

Porto, Portugal

Centro Hospitalar Universitário de Santo António
🇵🇹Porto, Portugal
André Ferreira, MD PhDc
Contact
+351 22 207 7500
andre.ferreira@live.com.pt
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