Microvascular Ocular Changes of Systemic Lupus Erythematous
- Conditions
- Eye ManifestationsLupus Erythematosus, Systemic
- Registration Number
- NCT05863689
- Lead Sponsor
- Universidade do Porto
- Brief Summary
The goal of this observational study is to to assess the ocular microvascular status of SLE patients with inactive disease and without ocular involvement. The main questions it aims to answer are:
* the choroidal vascular status and thickness in SLE
* the retinal macular microvascular status and structure in SLE
Participants will be assessed with Spectral Domain Optical Coherence Tomography (SD-OCT). Researchers will compare SLE patients with healthy controls matched for age and sex.
- Detailed Description
The investigators will perform a cross-sectional evaluation of 25 SLE patients and 25 healthy controls matched for sex and age, using a Spectral Domain Optical Coherence Tomography (SD-OCT) with Enhanced Depth Imaging for choroidal assessment and with Angiography module to assess the retinal and choriocapillaris vasculature. Processing of image with external software will be performed to calculate the main outcomes: retinal vessel density, foveal avascular zone parameters and the choroidal vascular index.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of choroidal vascular index 6 months Comparison of choroidal vascular index between SLE patients and healthy controls using OCT with Enhance Depth Imaging
Measurement of retinal vessel density 6 months Comparison of retinal vessel density of superficial and deep plexuses between SLE patients and healthy controls using OCT Angiography.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centro Hospitalar Universitário de Santo António
🇵🇹Porto, Portugal
Centro Hospitalar Universitário de Santo António🇵🇹Porto, PortugalAndré Ferreira, MD PhDcContact+351 22 207 7500andre.ferreira@live.com.pt