Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch

Recruiting

• Conditions: Lumbar Facet Arthrosis; Nerve Degeneration
• Interventions: Procedure: Spinal surgery; Other: Histology

• Registration Number: NCT05091112
• Lead Sponsor: University of Aberdeen

Brief Summary

The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.

Detailed Description

After written informed consent, the nerves supplying the facet joints - lumbar dorsal rami and its medial branches, will be harvested when they are exposed during spinal surgery. These nerves will be fixed, washed and further dissected to enable smaller sections. The cut section will be stained and subjected to analysis of overall cross-sectional area and presence of connective tissue sheaths under light microscope.

Study Timeline

• Study First Submitted: 2021-10-08
• Study First Submitted QC: 2021-10-22
• Study First Posted: 2021-10-25
• Study Start: 2022-03-08
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-18
• Last Update Posted: 2024-12-24
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Be aged 18 or over
• be able to give informed consent
• scheduled to undergo lumbar spinal surgery

Exclusion Criteria

• Children under 18 years old
• Vulnerable adults
• Adults with incapacity
• Inability to provide informed consent
• History of previous spinal surgery
• history of previous RF ablation for low back pain
• has COVID-19 or displaying symptoms of COVID-19

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Active group	Spinal surgery	Patients who are scheduled to undergo lumbar spinal surgery and fulfill the inclusion and exclusion criteria
Active group	Histology	Patients who are scheduled to undergo lumbar spinal surgery and fulfill the inclusion and exclusion criteria

Primary Outcome Measures

Name	Time	Method
Nerve Histology	one year	Percentage of nerves containing more than 50% sensory fibres in lumbar dorsal rami/medial branches to assess whether they are sensory or motor nerves

Trial Locations

Locations (1)

Woodend Hospital; 🇬🇧 Aberdeen, Scotland, United Kingdom