The Effect of Perioperative Magnesium Sulfate on Blood Sugar in Patients with Diabetes Mellitus Undergoing Cardiac Surgery: A Double-Blinded Randomized Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- to see the effect of magnesium sulfate infusion in reducing the blood sugar levls
研究概览
简要总结
we wish to see the effect of magnesium sulfate infusion on blood sugar in patients with diabetes mellitus undergoing cardiac surgery . Magnesium plays a very important role in glycolysis, uptake of glucose in cells by increasing insulin sensitivity and insulin secretion from pancreas. It also helps in maintaining normal levels of potassium in blood in post cardiopulmonary state , thereby reducing arrythmias and mortality. Magnesium will be given intravenously at the rate of 15mg/kg/hr, and levels of magnesium , potassium and blood glucose levels will be checked at predetermined time intervals and will be compared with patients receiving normal saline instead of magnesium sulfate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •all patients with adult age group and both sex with diabetes mellitus irrespective of the previous glycemic index control, but controlled baseline blood sugar levels in the past 24 hours of the surgery, LVEF> 40% presenting for cardiac surgery using CPB under general anaesthesia will be included in the study.
排除标准
- •patients with congestive heart failure, acute myocardial failure, emergency cases, redo cases, malfunctioning artificial heart valve,obstructive cardiomyopathy, heart rate <50bpm, pericardial disease, renal impairment, hepatic impairment.
结局指标
主要结局
to see the effect of magnesium sulfate infusion in reducing the blood sugar levls
时间窗: 0 min, 10 min after induction, before cardiopulmonary bypass, 30 min afte CPB, ICU admsiion, 6 hours after ICU admission,12 hours after admission, 24 hours after admission
次要结局
- blood potassium levels, blood magnesium levels, total requirement of insulin hospital stay, hemodynamic chasnges, side effect of drug(0 min, 10 min after induction, before cardiopulmonary bypass, 30 min afte CPB, ICU admsiion, 6 hours after ICU admission,12 hours after admission, 24 hours after admission)