The Effect of Intraoperative Magnesium Sulfate Infusion on the Occurrence of Emergence Agitation After Pediatric Ophthalmic Surgery
Overview
- Phase
- Phase 4
- Intervention
- Normal saline
- Conditions
- Agitation,Psychomotor
- Sponsor
- Seoul National University Bundang Hospital
- Enrollment
- 92
- Locations
- 1
- Primary Endpoint
- the incidence of emergence agitation (EA)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study designed to evaluate the correlation between the effect of intraoperative magnesium sulfate infusion and the incidence of emergence agitation after pediatric ophthalmic surgery
Detailed Description
Emergence agitation (EA) is a frequent postoperative complication in pediatric patients after general anesthesia. There are several suggested causes of EA and pain has been considered one of them. Magnesium is an N-methyl-D-aspartate (NMDA) receptor antagonist and increasingly used as an analgesic-adjuvant. We evaluate the Pediatric Anesthesia Emergence Delirium (PAED) Scale to investigate whether the intraoperative infusion of magnesium sulfate reduces the incidence of EA in pediatric patients who undergo ophthalmic outpatient surgery.
Investigators
LEE YEA JI
clinical professor
Seoul National University Bundang Hospital
Eligibility Criteria
Inclusion Criteria
- •pediatric patients who are planned to operate ophthalmic surgery under general anesthesia aged 4-7 years
Exclusion Criteria
- •ASA class ≥ III
- •imbalance of electrolyte
- •myocardial damage or conduction abnormality on ECG
- •myasthenia gravis or any other neuromuscular disease
- •impaired renal function
- •denial to participate in study or not be able to give informed consent
Arms & Interventions
Normal saline(NS) group
loading 50mL of normal saline during 10minutes before starting of surgery, after starting of surgery, continuous infusion of normal saline as placebo by 0.15mg/kg/h until the end of surgery
Intervention: Normal saline
Magnesium group
loading dose of 50mg/kg magnesium sulfate during 10minutes before starting of surgery, during the surgery, continuous infusion of magnesium sulfate by 15mg/kg/h
Intervention: Magnesium Sulfate
Outcomes
Primary Outcomes
the incidence of emergence agitation (EA)
Time Frame: 15 minute interval at the post-anesthetic care unit (PACU)
Using PAED (pediatric anesthesia emergence delirium) score, consider the score 10 or more as occuring of EA. Comparing the score between the placebo group and the intervention group for the difference of the incidence of EA.
Secondary Outcomes
- the severity of EA(15 minute interval at the post-anesthetic care unit (PACU))