Comparison of the Effect of Medium-Chain Fatty Acids and Long-Chain Fatty Acids on Postprandial Appetite and Lipemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Anthropometric measurements (percentage body fat)
研究概览
简要总结
The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).
详细描述
Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of postprandial triglyceride production and clearance in the blood, as well as the appetite, are influenced by the quality of the food consumed, such as the length of saturated fatty acids. The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both sexes and it will be conducted at the University of Jordan. The study will involve two experimental test days, each separated by at least a week of washout interval, and each test day will last for 6 hours. All subjects will be randomly assigned to one of the experimental meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] will be examined in a private lab. After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18-50 years
- •Males and females
- •Apparently healthy
- •Fasting triglyceride (TG) < 2.5 mmol/L or 222 mg/dl at the time of screening.
- •Body mass index (BMI) in normal range (18.5-24.9).
- •Stable weight for at least 3 months
排除标准
- •Consumption of lipid-lowering drugs or any medication that might affect appetite.
- •Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month.
- •Regular consumption of two or more fish meals a week over the previous month.
- •A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease.
- •Current smokers
- •Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS)
- •Being on a diet or lifestyle changes for the past month.
结局指标
主要结局
Anthropometric measurements (percentage body fat)
时间窗: baseline, pre-intervention,1 day for each participant /during 3 months
Bioelectrical impedance will be used to determine body composition
Dietary intake (3-days food record)
时间窗: one day
Participants will be asked to fill out a food record to track changes in their (intake) appetite
Anthropometric measurements (Weight)
时间窗: baseline, pre-intervention, 1 day for each participant /during 3 months
Bioelectrical impedance will be used to determine body weight
Anthropometric measurements ( Height)
时间窗: baseline, pre-intervention, 1 day for each participant /during 3 months
Standing height, without footwear, will be taken using stadiometer to the nearest 5mm
Anthropometric measurements (waist circumference)
时间窗: baseline, pre-intervention, 1 day for each participant /during 3 months
Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm
Biochemical measurements (Total cholesterol (TC))
时间窗: After the intervention / up to 3 months from collecting the samples
Up to 6 hours
Biochemical measurements (Low density lipoprotein cholesterol (LDL))
时间窗: Up to 6 hours
Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Biochemical measurements ( High density lipoprotein cholesterol (HDL))
时间窗: Up to 6 hours
High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Biochemical measurements (Triglyceride (TG))
时间窗: Up to 6 hours
Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
次要结局
未报告次要终点
研究者
Shatha Hammad, Assistant Professor
Assistant Professor
University of Jordan