Acute Effects of Canola Oil Compared With Coconut Oil on Postprandial Metabolism in Women and Men With Increased Risk for Cardiometabolic Diseases
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Bonn
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Parameters of lipid metabolism in blood I
Study Overview
Brief Summary
The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.
Detailed Description
In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, fatty acid profile, neuropsychologic parameters (e.g., attention), subjective feeling of hunger and satiety, and satiety-associated hormones (e.g., ghrelin) are assessed. Each intervention arm will be separated by a washout period of about 14 days.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 60 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •BMI: 27 - 34,9 kg/m2
- •Waist circumference: women ≥ 80 cm, men ≥ 94 cm
- •At least two of the following criteria of metabolic syndrome:
- •Fasting triglycerides in serum: ≥ 150 mg/dl Fasting HDL-Cholesterol in serum: women < 50 mg/dl, men < 40 mg/dl Systolic blood pressure: ≥ 130 mmHg, diastolic blood pressure: ≥ 85 mmHg Fasting glucose in plasma: ≥ 100 mg/dL
Exclusion Criteria
- •Diseases that may impact outcome measures (e.g., thyroid diseases, insulin-dependent diabetes mellitus, impaired renal function, tumors, anemia)
- •Intake of immunosuppressives or supplements (e.g., fish oil)
- •Participation in another study
Outcomes
Primary Outcomes
Parameters of lipid metabolism in blood I
Time Frame: Postprandial period of 6 hours
Measurement of triglycerides (mg/dl)
Parameters of lipid metabolism in blood II
Time Frame: Postprandial period of 6 hours
Measurement of total cholesterol (mg/dl)
Parameters of lipid metabolism in blood VI
Time Frame: Postprandial period of 6 hours
Measurement of free fatty acids (mmol/L)
Parameters of lipid metabolism in blood III
Time Frame: Postprandial period of 6 hours
Measurement of LDL cholesterol (mg/dl)
Parameters of lipid metabolism in blood IV
Time Frame: Postprandial period of 6 hours
Measurement of HDL cholesterol (mg/dl)
Parameters of glucose metabolism in blood I
Time Frame: Postprandial period of 6 hours
Measurement of glucose (mg/dl)
Parameters of glucose metabolism in blood II
Time Frame: Postprandial period of 6 hours
Measurement of insulin (nmol/L)
Secondary Outcomes
- Assessment of hunger and satiety(Postprandial period of 6 hours)
- Assessment of gut hormones(Postprandial period of 6 hours)
- Assessment of attention and memory(Postprandial period of 6 hours)
- Postprandial endothelial function(Postprandial period of 6 hours)
- Postprandial inflammation(Postprandial period of 6 hours)
- Antioxidant system(Postprandial period of 6 hours)
- Fatty acid profile(Postprandial period of 6 hours)
Investigators
Prof. Dr. Sarah Egert
Prof. Dr. Sarah Egert
University of Bonn