Acute Effects of Canola Oil Compared With Coconut Oil on Postprandial Metabolism in Women and Men With Increased Risk for Cardiometabolic Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Parameters of lipid metabolism in blood I
研究概览
简要总结
The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.
详细描述
In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, fatty acid profile, neuropsychologic parameters (e.g., attention), subjective feeling of hunger and satiety, and satiety-associated hormones (e.g., ghrelin) are assessed. Each intervention arm will be separated by a washout period of about 14 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •BMI: 27 - 34,9 kg/m2
- •Waist circumference: women ≥ 80 cm, men ≥ 94 cm
- •At least two of the following criteria of metabolic syndrome:
- •Fasting triglycerides in serum: ≥ 150 mg/dl Fasting HDL-Cholesterol in serum: women < 50 mg/dl, men < 40 mg/dl Systolic blood pressure: ≥ 130 mmHg, diastolic blood pressure: ≥ 85 mmHg Fasting glucose in plasma: ≥ 100 mg/dL
排除标准
- •Diseases that may impact outcome measures (e.g., thyroid diseases, insulin-dependent diabetes mellitus, impaired renal function, tumors, anemia)
- •Intake of immunosuppressives or supplements (e.g., fish oil)
- •Participation in another study
结局指标
主要结局
Parameters of lipid metabolism in blood I
时间窗: Postprandial period of 6 hours
Measurement of triglycerides (mg/dl)
Parameters of lipid metabolism in blood II
时间窗: Postprandial period of 6 hours
Measurement of total cholesterol (mg/dl)
Parameters of lipid metabolism in blood VI
时间窗: Postprandial period of 6 hours
Measurement of free fatty acids (mmol/L)
Parameters of lipid metabolism in blood III
时间窗: Postprandial period of 6 hours
Measurement of LDL cholesterol (mg/dl)
Parameters of lipid metabolism in blood IV
时间窗: Postprandial period of 6 hours
Measurement of HDL cholesterol (mg/dl)
Parameters of glucose metabolism in blood I
时间窗: Postprandial period of 6 hours
Measurement of glucose (mg/dl)
Parameters of glucose metabolism in blood II
时间窗: Postprandial period of 6 hours
Measurement of insulin (nmol/L)
次要结局
- Assessment of hunger and satiety(Postprandial period of 6 hours)
- Assessment of gut hormones(Postprandial period of 6 hours)
- Assessment of attention and memory(Postprandial period of 6 hours)
- Postprandial endothelial function(Postprandial period of 6 hours)
- Postprandial inflammation(Postprandial period of 6 hours)
- Antioxidant system(Postprandial period of 6 hours)
- Fatty acid profile(Postprandial period of 6 hours)
研究者
Prof. Dr. Sarah Egert
Prof. Dr. Sarah Egert
University of Bonn