The efficacy of tonifying Kidney and benefiting Marrow method for the a-synuclein diseases (PD, MSA) on the theory of treating different diseases with the same treatment and discussion of TCM pathogenesis
- Conditions
- Multisystem atrophy, Parkinson's disease
- Registration Number
- ITMCTR2100004930
- Lead Sponsor
- Dongfang Hospital of Beijing University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. According to the diagnosis of PD and MSA, the patients aged 30 to 80 years;
2. All the included cases were selected as mild and moderate patients;
3. According to Hoya classification (HY), the patients with HY 3 were selected as PD patients, and the PD evaluation time was selected as the opening time, 1.5-3 hours after taking medicine;
4. According to the unified multiple system atrophy assessment scale (UMSARS-IV), the patients with UMSARS-IV <=3 were selected as MSA patients Patients in the hospital.
1. Nervous system examination showed that there were brain atrophy or dementia caused by systemic diseases or other clear reasons, such as severe depression, cerebrovascular disease, poisoning and metabolic diseases;
2. Obvious slowing down of vertical rapid scanning or vertical supranuclear gaze paralysis;
3. Evidence of local cerebral cortex damage, such as aphasia, allopathy, parietal lobe dysfunction; pregnant women, with severe heart, liver and kidney diseases that who can not complete the scale and related examinations.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MSARS-I, II;MSA-NMSS;TCM Syndrome Scale of Kidney Deficiency and Pulp Reduction;Hoehn-Yahr (H-Y) staging score;NMSS;DTI, fMRI (BOLD);unified Parkinson disease rating scale, UPDRS-U-3;
- Secondary Outcome Measures
Name Time Method