Exercise, Glucose Kinetics, and the Incretin Effect

Not Applicable

Completed

• Conditions: Type 2 Diabetes
• Interventions: Behavioral: Exercise

• Registration Number: NCT01607931
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Human volunteers will be stratified by oral glucose tolerance status: normal glucose tolerant, impaired glucose tolerant, and type 2 diabetic. All subjects will undergo 4 experimental trials: \[1\] an oral glucose tolerance test (OGTT) combined with infused and ingested stable isotopes of glucose to assess glucose kinetics. \[2\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by the same OGTT combined with stable isotope glucose tracers used in trial 1. \[3\] an isoglycemic clamp to match the plasma glucose profile measured in trial 1. \[4\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by an isoglycemic clamp to match the plasma glucose profile measured in trial 2.

Exercise-induced changes in oral glucose tolerance, glucose kinetics, insulin and glucagon secretion, and the incretin effect will be examined. The exercise responses will be compared between the subjects groups of different glucose tolerance status.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-05-23
• Study First Submitted QC: 2012-05-25
• Study First Posted: 2012-05-30
• Study Start: 2013-01
• Primary Completion: 2016-04
• Study Completion: 2016-07
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-11
• Last Update Posted: 2016-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• age 18-60 years
• BMI 18-35 kg/m2

Exclusion Criteria

• insulin dependency
• pregnancy
• presence or history of chronic cardiovascular, pulmonary, hepatic, renal, or hematological disease, or cancer
• contraindication to physical activity as assessed by ECG

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise Trial	Exercise	a 1 hour cycling exercise bout immediately prior to the OGTT or isoglycemic clamp

Primary Outcome Measures

Name	Time	Method
Glucose tolerance	Plasma glucose will be measured at 10 minute intervals during the OGTT (3 hours) immediately following the period of rest or exercise
Incretin effect	Plasma insulin and C-peptide will be measured at 10 minute intervals during the OGTT (3 hours) and isoglycemic clamp (3 hours) immediately following the period of rest or exercise

Trial Locations

Locations (1)

Rigshospitalet; 🇩🇰 Copenhagen, Denmark