The efficacy of trisodium citrate versus heparin for permanent cuffed tunneled catheter lock in chronic hemodialysis patients

Phase 2

• Conditions: chronic hemodialysis; locking solution; citrate; permanent catheter; hemodialysis

• Registration Number: TCTR20230107004
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-07
• Last Update Posted: 19 August 2024
• Study Completion: 2025-02-28

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

1. Chronic hemodialysis patients via tunneled-cuffed catheter
2. Newly inserted tunneled-cuffed catheter for hemodialysis at right internal jugular vein
3. Age more than 18 years

Exclusion Criteria

1. Patients that refuse to give consent
2. Previously diagnosis of heparin induced thrombocytopenia
3. Severe liver impairment
4. Patients on cardiac pacemaker or with uncontrolled cardiac arrhythmia
5. Serum calcium less than 8.4 mg/dl within 2 months before enrollment
6. Patients currently on systemic anticoagulant
7. History of allergy to heparin or trisodium citrate
8. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CRBSI 1 year events per catheter-days,catheter dusfunction 1 year events per catheter-days

Secondary Outcome Measures

Name	Time	Method
exit-site infection 1 year events per catheter-days,tunnel infection 1 year events per catheter-days,catheter removal 1 year time to event,mortality 1 year rate,cost-effectiveness 1 year cost utility analysis