Efficacy of 5%, 10% trisodium citrate and heparin as catheter-locking solution for central venous hemodialysis catheters: A prospective randomized study
Not Applicable
- Conditions
- The patients who need hemodialysis catheter insertionCatheter locking solutionHeparinTrisodium citrateHemodialysis catheter
- Registration Number
- TCTR20170314002
- Lead Sponsor
- Pattharawin Pattharanitima
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 249
Inclusion Criteria
- Age of 18 years, or more
- The patients who need hemodialysis catheter insertion (newly insertion of non-tunnel cuff catheter and tunnel-cuff cathterter in appropriate location) and expected to be retained more than 7 days
- The patients who have existed tunnel-cuffed catheter and able to obtain blood from catheter lumens at rate more than 250 ml/min
Exclusion Criteria
The patients who had
- HIT
- Allergic to heparin, or trisodium citrate
- Pregnancy
- Bleeding diathesis
- Thrombocytopenia
- Hypercoagulable state
- Recieved warfarin, enoxaparin, rivaroxaban, apixaban, or dabigatran
- Refuse to join the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Catheter dysfunction During 3 months after include into study Obtain blood flow rate less than 250 ml/min, or need rt-PA treatment for catheter dysfunction
- Secondary Outcome Measures
Name Time Method Catheter-related blood stream infection (CRBSI) During 3 months after include into study Rate of CRBSI per 1,000 catheter-day,Exit-site infection During 3 months after include into study Rate of CRBSI per 1,000 catheter-day,All-cause death During 3 months after include into study Rate of CRBSI per 1,000 catheter-day,Side effects (bleeding class 3A-5, and other side effect) During 3 months after include into study Rate of CRBSI per 1,000 catheter-day