Efficacy of 5% Trisodium Citrate and Low Dose Heparin as Catheter-Locking Solution for Central Venous Hemodialysis Catheters: A Randomized Controlled Study
- Conditions
- Central venous catheter dysfunction (CVC dysfunction) is failure to maintain the prescribed extracorporeal blood flow required for adequate hemodialysis without lengthening the prescribed HD treatment. A catheter locking anticoagulant (CLA) by trisodium citrate (TSC) or unfractionated heparin (UFH) is recommended in real practice to prevent this problem.Central venous catheter dysfunction, CVC dysfunction, Catheter locking anticoagulant, CLA, Trisodium citrate, TSC, Unfractionated heparin, UFH
- Registration Number
- TCTR20231106002
- Lead Sponsor
- Thammasat University Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 216
1. Hemodialysis patients, 2. Well-positioned of non-tunnel cuffed catheter (NTCC) or tunnel cuffed catheter (TCC) expected to be needed for more than 1 week without flow problems (a persistent inability to obtain blood flow rate [BFR] above 250 mL/minute)
1. Hemorrhagic diathesis conditions (liver failure, disseminated intravascular coagulopathy, leukemia, vitamin K deficiency, hemophilia, or thrombocytopenia), 2. Hypercoagulable states (deep vein thrombosis, pulmonary embolism, or antiphospholipid syndrome), 3. Hematologic diseases (paroxysmal nocturnal hemoglobinuria, myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis, or hemolytic anemia), 4. Metastatic cancer, 5. Currently using of oral contraceptive pills, 6. Currently using one of the following anticoagulants: warfarin, UFH, enoxaparin, rivaroxaban, apixaban, or dabigatran, 7. Proven or suspected heparin induced thrombocytopenia, 8. Allergic to UFH or TSC, 9. Pregnant, 10. Unable to obtain crucial data, 11. Refused to participate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of Catheter dysfunction (CD) At 3 months after end of the intervention Percentage
- Secondary Outcome Measures
Name Time Method Rates of catheter related blood stream infection(CRBSI) At 3 months after end of the intervention Percentage,Exit site infection (ESI) At 3 months after end of the intervention Percentage,Bleeding episodes At 3 months after end of the intervention Events