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Quantification of Nerve Stiffness in Neuropathies

Not Applicable
Completed
Conditions
Anti-MAG Neuropathy
Charcot-Marie-Tooth Disease, Type IA
Chronic Inflammatory Demyelinating Polyneuropathy
Registration Number
NCT03397303
Lead Sponsor
Nantes University Hospital
Brief Summary

This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound shear wave elastography. Patients will be compared with age-matched controls.

Detailed Description

The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial.

Participants will be asked to remain relaxed during elastography measurements.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
36
Inclusion Criteria
  • Male or female aged 18 to 65
  • Having social insurance status
  • Having given informed consent
  • Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)>15,000 BTU)
Exclusion Criteria

For controls:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress
  • Diabetes, history of neuromuscular disease

For CIDP:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress
  • MRC score < 3

For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:

  • Person staying in a health or social facility
  • Person unable to understand the protocol and to respect the modalities
  • Person deprived of liberty
  • Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
  • Participation in another biomedical research in progress

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
nerve shear wave velocityDay0

Ultrasound shear wave elastography will provide a measure of nerve shear wave velocity, which will be used as a surrogate of nerve stiffness.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Univeristy of Nantes

🇫🇷

Nantes, France

Univeristy of Nantes
🇫🇷Nantes, France
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