Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.
Not Applicable
Completed
- Conditions
- Obstructive Sleep Apnea
- Interventions
- Other: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
- Registration Number
- NCT02876653
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 53
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy volunteers Polysomnography , blood collection, bone densitometry and Functional respiratory explorations Healthy volunteers (AHI ≤ 5) Moderate OSA Polysomnography , blood collection, bone densitometry and Functional respiratory explorations Patients with moderate OSA (5 \< AHI ≤ 30) Severe OSA Polysomnography , blood collection, bone densitometry and Functional respiratory explorations Patients with severe OSA (AHI \> 30)
- Primary Outcome Measures
Name Time Method Telomere length of circulating leukocytes 4 weeks
- Secondary Outcome Measures
Name Time Method Carotid-femoral pulse wave velocity 4 weeks Markers of oxidative stress: Malondialdehyde, heme oxygenase-1 4 weeks Markers of growth hormone axis (GH, IGF-1, IGFBP) 4 weeks Bone density 4 weeks Correlation between biological parameters and neuropsychological assessment 4 weeks Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1 4 weeks
Trial Locations
- Locations (1)
Henri Mondor Hospital
🇫🇷Creteil, France