Assessment of myocardial function, metabolism, and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM
- Conditions
- Enlarged heart muscle disease1002859310007510
- Registration Number
- NL-OMON49221
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 105
Inclusion Criteria
MYBPC3 mutation carrier
MYH7 mutation carrier
Genotype-negative first degree relative of a MYBPC3 or MYH7 mutation carriers
Exclusion Criteria
>=65 years old
Diabetes mellitus
Pregnancy
Claustrophobia
Pacemaker/ICD
Renal insufficiency <60 GFR
Hypertension
Aortic valve disease
BMI >30 kg/m2
Left bundle branch block
Obstructive coronary artery disease
Atrial fibrillation
Hormone replacement therapy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>myocardial fatty acid oxidation, uptake and esterification, glucose uptake en<br /><br>oxidation, perfusion, function and volume parameters of the heart</p><br>
- Secondary Outcome Measures
Name Time Method <p>biomarker analysis</p><br>